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Molecules 2018, 23(7), 1554; https://doi.org/10.3390/molecules23071554

Magnetic Porous Molecularly Imprinted Polymers Based on Surface Precipitation Polymerization and Mesoporous SiO2 Layer as Sacrificial Support for Efficient and Selective Extraction and Determination of Chlorogenic Acid in Duzhong Brick Tea

1
Provincial Public Laboratory of Analysis and Testing Technology, Guangdong Institute of Analysis, Guangzhou 510070, China
2
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
3
National & Local United Engineering laboratory of Integrative Utilization Technology of Eucommia ulmoides, Jishou University, Jishou 416000, China
4
School of Mathematics and Statistics, Central South University, Changsha 410083, China
*
Authors to whom correspondence should be addressed.
Received: 3 May 2018 / Revised: 15 June 2018 / Accepted: 23 June 2018 / Published: 27 June 2018
(This article belongs to the Special Issue Synthesis and Applications of Molecularly Imprinted Polymers)
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Abstract

Magnetic porous molecularly imprinted polymers (MPMIPs) for rapid and efficient selective recognition of chlorogenic acid (CGA) were effectively prepared based on surface precipitation polymerization using CGA as template, 4-vinylpyridine (4-VP) as functional monomer, and mesoporous SiO2 (mSiO2) layer as sacrificial support. A computational simulation by evaluation of electronic binding energy is used to optimize the stoichiometric ratio between CGA and 4-VP (1:5), which reduced the duration of laboratory trials. The porous MIP shell and the rid of solid MIPs by magnet gave MPMIPs high binding capacity (42.22 mg/g) and fast kinetic binding (35 min). Adsorption behavior between CGA and MPMIPs followed Langmuir equation and pseudo-first-order reaction kinetics. Furthermore, the obtained MPMIPs as solid phase adsorbents coupled with high performance liquid chromatography (HPLC) were employed for selective extraction and determination of CGA (2.93 ± 0.11 mg/g) in Duzhong brick tea. The recoveries from 91.8% to 104.2%, and the limit of detection (LOD) at 0.8 μg/mL were obtained. The linear range (2.0–150.0 μg/mL) was wide with R2 > 0.999. Overall, this study provided an efficient approach for fabrication of well-constructed MPMIPs for fast and selective recognition and determination of CGA from complex samples. View Full-Text
Keywords: surface precipitation polymerization; mesoporous SiO2; selective extraction; chlorogenic acid; Duzhong brick tea surface precipitation polymerization; mesoporous SiO2; selective extraction; chlorogenic acid; Duzhong brick tea
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Peng, M.; Li, H.; Long, R.; Shi, S.; Zhou, H.; Yang, S. Magnetic Porous Molecularly Imprinted Polymers Based on Surface Precipitation Polymerization and Mesoporous SiO2 Layer as Sacrificial Support for Efficient and Selective Extraction and Determination of Chlorogenic Acid in Duzhong Brick Tea. Molecules 2018, 23, 1554.

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