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Molecules 2018, 23(6), 1481; https://doi.org/10.3390/molecules23061481

Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum

1
Marbio, UiT—The Arctic University of Norway, Breivika, N-9037 Tromsø, Norway
2
Department of Chemistry, UiT—The Arctic University of Norway, Breivika, N-9037 Tromsø, Norway
*
Author to whom correspondence should be addressed.
Received: 18 May 2018 / Revised: 11 June 2018 / Accepted: 12 June 2018 / Published: 19 June 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

A new ecdysteroid, ponasterone F (1) and the previously reported compound ponasterone A (2) were isolated from specimens of the Arctic marine bryozoan Alcyonidium gelatinosum collected at Hopenbanken, off the coast of Edgeøya, Svalbard. The structure of 1 was elucidated, and the structure of 2 confirmed by spectroscopic methods including 1D and 2D NMR and analysis of HR-MS data. The compounds were evaluated for their ability to affect bacterial survival and cell viability, as well as their agonistic activities towards the estrogen receptors α and β. The compounds were not active in these assays. Compound 2 is an arthropod hormone controlling molting and are known to act as an allelochemical when produced by plants. Even though its structure has been previously reported, this is the first time a ponasterone has been isolated from a bryozoan. A. gelatinosum produced 1 and 2 in concentrations surpassing those expected of hormonal molecules, indicating their function as defence molecules against molting predators. This work adds to the chemical diversity reported from marine bryozoans and expanded our knowledge of the chemical modifications of the ponasterones. View Full-Text
Keywords: marine bryozoan; Alcyonidium gelatinosum; ponasterone; ecdysteroids; marine bioprospecting; allelochemicals marine bryozoan; Alcyonidium gelatinosum; ponasterone; ecdysteroids; marine bioprospecting; allelochemicals
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hansen, K.Ø.; Isaksson, J.; Glomsaker, E.; Andersen, J.H.; Hansen, E. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules 2018, 23, 1481.

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