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Molecules 2018, 23(6), 1429;

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

Yenepoya Research Center, Yenepoya (Deemed to Be University), Deralakatte, Mangalore 575018, Karnataka, India
Division of Bioengineering, Incheon National University, Incheon 22012, Korea
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India
Marine Bioprocess Research Centre and Department of Marine Bio-Convergence Science, Pukyong National University, Sinseon-ro 365, Nam-gu, Busan 608739, Korea
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha University, Poonamallee High Road, Chennai 600077, India
Authors to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 19 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 12 June 2018
Full-Text   |   PDF [5949 KB, uploaded 12 June 2018]   |  


Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis of AgNPs was developed using seaweed polysaccharide fucoidan. The AgNPs were further coated with chitosan to form an electrolyte complex on the surface. The developed chitosan–fucoidan complex-coated AgNPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). FT-IR results suggested strong polyelectrolyte complexation between fucoidan and chitosan. The developed chitosan–fucoidan complex-coated AgNPs significantly inhibited microbial growth. Moreover, the AgNPs showed efficient anticancer activity in human cervical cancer cells (HeLa). This study demonstrated that chitosan–fucoidan complex-coated AgNPs hold high potential for food and cosmeceutical applications. View Full-Text
Keywords: chitosan; fucoidan; silver nanoparticles; antimicrobial activity chitosan; fucoidan; silver nanoparticles; antimicrobial activity

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Venkatesan, J.; Singh, S.K.; Anil, S.; Kim, S.-K.; Shim, M.S. Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating. Molecules 2018, 23, 1429.

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