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Article

Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation

1
Institute of Pharmaceutical Technology, Lithuanian University of Health Sciences, Medical Academy, Sukileliu pr. 13, LT-50162 Kaunas, Lithuania
2
Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Medical Academy, Sukileliu pr. 13, LT-50162 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Locatelli
Molecules 2018, 23(6), 1428; https://doi.org/10.3390/molecules23061428
Received: 17 May 2018 / Revised: 7 June 2018 / Accepted: 11 June 2018 / Published: 12 June 2018
(This article belongs to the Special Issue Natural Product Pharmacology and Medicinal Chemistry)
The increased interest in natural cosmetics has resulted in a higher market demand for preservative-free products based on herbal ingredients. An innovative W/O/W type emulsions containing herbal extracts were prepared directly; its cation form was induced by an ethanolic rosemary extract and stabilized using weak herbal gels. Due to the wide phytochemical composition of herbal extracts and the presence of alcohol in the emulsion system, which can cause skin irritation, sensitization or dryness when applied topically, the safety of the investigated drug delivery system is necessary. The aim of our study was to estimate the potential of W/O/W emulsions based on natural ingredients for skin irritation and phototoxicity using reconstructed 3D epidermis models in vitro and to evaluate in vivo its effect on human skin moisture, sebum content and pigmentation by biomedical examination using a dermatoscopic camera and corneometer. According to the results obtained after in vitro cell viability test the investigated emulsion was neither irritant nor phototoxic to human skin keratinocytes. W/O/W emulsion did not cause skin dryness in vivo, despite the fact that it contained ethanol. We can conclude that the emulsion is safe for use as a leave-on product due to the positive effect on human skin characteristics or as a semisolid pharmaceutical base where active compounds could be encapsulated. View Full-Text
Keywords: multiple emulsion; Rosmarinus officinalis; Avena sativa; Linum usitatissimum; skin moisture; pigmentation; pore size multiple emulsion; Rosmarinus officinalis; Avena sativa; Linum usitatissimum; skin moisture; pigmentation; pore size
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MDPI and ACS Style

Cizauskaite, U.; Bernatoniene, J. Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation. Molecules 2018, 23, 1428. https://doi.org/10.3390/molecules23061428

AMA Style

Cizauskaite U, Bernatoniene J. Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation. Molecules. 2018; 23(6):1428. https://doi.org/10.3390/molecules23061428

Chicago/Turabian Style

Cizauskaite, Ugne, and Jurga Bernatoniene. 2018. "Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation" Molecules 23, no. 6: 1428. https://doi.org/10.3390/molecules23061428

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