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Molecules 2018, 23(6), 1426; https://doi.org/10.3390/molecules23061426

Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity

1
Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, China
2
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China
*
Author to whom correspondence should be addressed.
Received: 23 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 12 June 2018
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Abstract

Seven new triterpenoid saponins (17), together with three known ones (810), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells. View Full-Text
Keywords: Ilex pubescens; anti-inflammation; RAW264.7 Ilex pubescens; anti-inflammation; RAW264.7
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Qiao, X.; Ji, M.; Yao, Y.; Ma, L.; Wu, J.; Liao, G.; Zhou, H.; Liu, Z.; Wu, P. Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity. Molecules 2018, 23, 1426.

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