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Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

Research Centre for Crystalline Materials, School of Science and Technology, Sunway University. No. 5, Jalan Universiti, Bandar Sunway 47500, Malaysia
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(6), 1410; https://doi.org/10.3390/molecules23061410
Received: 6 April 2018 / Revised: 23 May 2018 / Accepted: 28 May 2018 / Published: 11 June 2018
(This article belongs to the Special Issue Functional Molecular Materials)
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent platinum-based complexes, commencing with cisplatin [(H3N)2PtCl2], which are effective anti-cancer chemotherapeutic drugs. While clinical applications of gold-based drugs largely relate to the treatment of rheumatoid arthritis, attention has turned to the investigation of the efficacy of gold(I) and gold(III) compounds for anti-cancer applications. This review article provides an account of the latest research conducted during the last decade or so on the development of gold compounds and their potential activities against several cancers as well as a summary of possible mechanisms of action/biological targets. The promising activities and increasing knowledge of gold-based drug metabolism ensures that continued efforts will be made to develop gold-based anti-cancer agents. View Full-Text
Keywords: gold compounds; biological activities; cancer; metabolism gold compounds; biological activities; cancer; metabolism
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Yeo, C.I.; Ooi, K.K.; Tiekink, E.R.T. Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy? Molecules 2018, 23, 1410.

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