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Molecules 2018, 23(6), 1406; https://doi.org/10.3390/molecules23061406

Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention

1
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa
2
Department of Applied Chemistry, University of Johannesburg, 27 Nind Street, Doornfontein, Johannesburg 2028, South Africa
*
Author to whom correspondence should be addressed.
Received: 30 April 2018 / Revised: 1 June 2018 / Accepted: 7 June 2018 / Published: 10 June 2018
(This article belongs to the Special Issue Stimuli-Responsive Polymeric Materials)
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Abstract

The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2θ of 25° and iron at 2θ of 45° in MWCNTs was illustrated by XRD. Polydispersive index and zeta potential were found to be 0.261 and −15.0 mV, respectively. Dexamethasone release increased by 55%, 65% and 95% in pH of 7.4, 6.5 and 5.5 respectively as evaluated by UV-VIS. The functionalized VA-MWCNTs were demonstrated to be less toxic in PC-12 cells in the concentration range from 20 to 20,000 µg/mL. These findings have demonstrated the potential of VA-MWCNTs in the enhancement of fast and prolonged release of dexamethasone which could lead to the effective treatment of ischemic stroke. More work is under way for targeting ischemic sites using atrial natriuretic peptide antibody in stroke rats. View Full-Text
Keywords: multiwalled carbon nanotubes; chemical functionalization; chemical vapor deposition; PEGylation; ischemic stroke article; yet reasonably common within the subject discipline multiwalled carbon nanotubes; chemical functionalization; chemical vapor deposition; PEGylation; ischemic stroke article; yet reasonably common within the subject discipline
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Komane, P.P.; Kumar, P.; Marimuthu, T.; Toit, L.C.; Kondiah, P.P.D.; Choonara, Y.E.; Pillay, V. Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention. Molecules 2018, 23, 1406.

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