Next Article in Journal
Expression Analysis of Oxalate Metabolic Pathway Genes Reveals Oxalate Regulation Patterns in Spinach
Next Article in Special Issue
In Vitro Antioxidant Activities of Phenols and Oleanolic Acid from Mango Peel and Their Cytotoxic Effect on A549 Cell Line
Previous Article in Journal
A Modified GC-MS Analytical Procedure for Separation and Detection of Multiple Classes of Carbohydrates
Previous Article in Special Issue
Effect of Microwave Vacuum Drying on the Drying Characteristics, Color, Microstructure, and Antioxidant Activity of Green Coffee Beans
Open AccessFeature PaperArticle

Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

Campus de Santiago, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal
Unité de Recherche et Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-chimiques et Biologiques, Université des Frères Mentouri Constantine 1, Constantine, Algeria
Author to whom correspondence should be addressed.
Molecules 2018, 23(6), 1285;
Received: 14 April 2018 / Revised: 22 May 2018 / Accepted: 24 May 2018 / Published: 27 May 2018
(This article belongs to the Special Issue The Antioxidant Capacities of Natural Products)
The phenolic profile of Scabiosa stellata L., a species used in Moroccan traditional medicine, is disclosed. To obtain that profile the species extract was analyzed by ultra-high-performance chromatography coupled to photodiode-array detection and electrospray ionization/ion trap mass spectrometry (UHPLC-DAD-ESI/MSn). Twenty-five phenolic compounds were identified from which isoorientin and 4-O-caffeoylquinic acid can be highlighted because they are the major ones. The antioxidant activity was significantly controlled by the fraction type, with the n-butanol fraction showing the highest antioxidant activity (FRS50 = 64.46 µg/mL in the DPPH assay, FRS50 = 27.87 µg/mL in the ABTS assay and EC50 = 161.11 µg/mL in the reducing power assay). A phytochemical study of the n-butanol fraction was performed, and some important flavone glycosides were isolated. Among them the tamarixetin derivatives—the less common ones—can be emphasized. This phytochemical study and polyphenolic profile can be correlated with S. stellata extracts in vitro antioxidant activity. Moreover, it can be regarded as an evidence of its medicinal use and can incentivize its consumption. View Full-Text
Keywords: Scabiosa stellata L.; phenolic profile; antioxidant activity; UHPLC-MS; NMR; flavone glycosides Scabiosa stellata L.; phenolic profile; antioxidant activity; UHPLC-MS; NMR; flavone glycosides
Show Figures

Graphical abstract

MDPI and ACS Style

Rahmouni, N.; Pinto, D.C.G.A.; Beghidja, N.; Benayache, S.; Silva, A.M.S. Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity. Molecules 2018, 23, 1285.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop