Next Article in Journal
Determination of Chlortetracycline Residues, Antimicrobial Activity and Presence of Resistance Genes in Droppings of Experimentally Treated Broiler Chickens
Previous Article in Journal
Profile of Polyphenolic and Essential Oil Composition of Polish Propolis, Black Poplar and Aspens Buds
Open AccessArticle

Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum

State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1263;
Received: 10 April 2018 / Revised: 22 May 2018 / Accepted: 22 May 2018 / Published: 25 May 2018
(This article belongs to the Section Natural Products Chemistry)
Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC50 value of 18.2 µM. View Full-Text
Keywords: Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity
Show Figures

Figure 1

MDPI and ACS Style

Zhao, C.; Fu, P.; Zhang, Y.; Liu, X.; Ren, F.; Che, Y. Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum. Molecules 2018, 23, 1263.

AMA Style

Zhao C, Fu P, Zhang Y, Liu X, Ren F, Che Y. Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum. Molecules. 2018; 23(6):1263.

Chicago/Turabian Style

Zhao, Chen; Fu, Peinan; Zhang, Yang; Liu, Xingzhong; Ren, Fengxia; Che, Yongsheng. 2018. "Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum" Molecules 23, no. 6: 1263.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop