Molecules 2018, 23(5), 1159; https://doi.org/10.3390/molecules23051159
First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
Institut de Chimie Organique et Analytique, Université d’Orléans—Pôle de Chimie, UMR CNRS 7311, Rue de Chartres—BP 6759, 45067 Orléans CEDEX 2, France
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Received: 24 April 2018 / Revised: 4 May 2018 / Accepted: 8 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
Abstract
We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced. View Full-TextKeywords:
metal-free; thienopyrimidinone; tetracyclic compounds
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Aounzou, M.; Campos, J.F.; Loubidi, M.; Berteina-Raboin, S. First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules. Molecules 2018, 23, 1159.
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