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Open AccessArticle

First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules

Institut de Chimie Organique et Analytique, Université d’Orléans—Pôle de Chimie, UMR CNRS 7311, Rue de Chartres—BP 6759, 45067 Orléans CEDEX 2, France
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Molecules 2018, 23(5), 1159; https://doi.org/10.3390/molecules23051159
Received: 24 April 2018 / Revised: 4 May 2018 / Accepted: 8 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced. View Full-Text
Keywords: metal-free; thienopyrimidinone; tetracyclic compounds metal-free; thienopyrimidinone; tetracyclic compounds
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MDPI and ACS Style

Aounzou, M.; Campos, J.F.; Loubidi, M.; Berteina-Raboin, S. First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules. Molecules 2018, 23, 1159.

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