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Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents

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REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal
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IINFACTS—Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Central de Gandra Street, 1317, 4585-116 Gandra PRD, Portugal
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Departamento de Microscopia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal
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Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), 4450-208 Matosinhos, Portugal
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Departamento de Ciências da Vida, Universidade Lusófona de Humanidades e Tecnologia, 1749-024 Lisboa, Portugal
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MARE NOVA. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Departamento de Ciências e Engenharia do Ambiente, Campus da Caparica, 2829-516 Caparica, Portugal
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Authors to whom correspondence should be addressed.
Molecules 2018, 23(5), 1027; https://doi.org/10.3390/molecules23051027
Received: 15 March 2018 / Revised: 24 April 2018 / Accepted: 25 April 2018 / Published: 27 April 2018
Bioprospection of marine invertebrates has been predominantly biased by the biological richness of tropical regions, thus neglecting macro-organisms from temperate ecosystems. Species that were not the object of studies on their biochemical composition include the Heterobranchia gastropods Armina maculata, Armina tigrina and Aglaja tricolorata, inhabitants of the Portuguese Atlantic coastal waters. Here, we present for the first time the fatty acid profile of neutral lipids and homarine content of these three species. Qualitative and quantitative differences in the fatty acid content among species points to the existence of a fatty acid profile of neutral lipids, particularly of each genus. The results from cytotoxicity assays, using the acetonic extracts of the gastropods on human gastric adenocarcinoma (AGS) and human lung adenocarcinoma (A549) cell lines, revealed a pronounced cytotoxic effect of the A. tigrina extract on both cell lines (IC50 values of 68.75 and 69.77 μg mL−1 for AGS and A549, respectively). It is worth noting the significant reduction of NO levels in LPS-challenged RAW 264.7 macrophages exposed to A. tricolorata extract, at concentrations as low as 125 μg mL−1. View Full-Text
Keywords: Armina spp.; Aglaja tricolorata; sea slugs; fatty acids; PUFA; EPA; DHA; homarine Armina spp.; Aglaja tricolorata; sea slugs; fatty acids; PUFA; EPA; DHA; homarine
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Gomes, N.G.M.; Fernandes, F.; Madureira-Carvalho, Á.; Valentão, P.; Lobo-da-Cunha, A.; Calado, G.; Andrade, P.B. Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents. Molecules 2018, 23, 1027.

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