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Synthesis of Theaflavins and Their Functions

School of Pharmaceutical Sciences, Ohu University, 31-1 Tomitamachi-Aza Misumido, Koriyama, Fukushima 963-8611, Japan
School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Mamoru Isemura
Molecules 2018, 23(4), 918;
Received: 9 March 2018 / Revised: 11 April 2018 / Accepted: 12 April 2018 / Published: 16 April 2018
(This article belongs to the Special Issue Catechin in Human Health and Disease)
Numerous epidemiological and interventional clinical studies have consistently reported that black tea is good for human health. The polyphenolic compound, theaflavin, and its galloyl esters (theaflavins) are the primary red pigments in black tea that possess several health benefits, including fat-reducing and glucose-lowering capabilities and lifestyle-related disease prevention related to anti-obesity, anticancer, anti-atherosclerotic, anti-inflammatory, antiviral, antibacterial, anti-osteoporotic, and anti-dental caries properties. These compounds are produced by key enzymes, such as polyphenol oxidase and peroxidase, from parent green tea catechins present in fresh green tea leaves during the production of black tea leaves or the fermentation of green tea. However, theaflavins are only present in low concentrations in black tea; thus, their extraction from black tea leaves at sufficient levels for use in medical studies has been difficult. To circumvent this issue, different procedures for the synthesis of theaflavins using chemical oxidizing reagents or enzymes have been studied; however, low yields have limited their utility. Recently, however, several biosynthetic methods have been developed for the mass production of theaflavins. Using these methods, the physiological functions of theaflavins in lifestyle-related diseases in mice and humans have also been studied. In this review, we present the synthesis of theaflavins and their health benefits. View Full-Text
Keywords: black tea; theaflavins; synthesis; physiological functions; polyphenol oxidase; peroxidase black tea; theaflavins; synthesis; physiological functions; polyphenol oxidase; peroxidase
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MDPI and ACS Style

Takemoto, M.; Takemoto, H. Synthesis of Theaflavins and Their Functions. Molecules 2018, 23, 918.

AMA Style

Takemoto M, Takemoto H. Synthesis of Theaflavins and Their Functions. Molecules. 2018; 23(4):918.

Chicago/Turabian Style

Takemoto, Masumi, and Hiroaki Takemoto. 2018. "Synthesis of Theaflavins and Their Functions" Molecules 23, no. 4: 918.

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