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Molecules 2018, 23(3), 676; https://doi.org/10.3390/molecules23030676

Anti-Amyloid Aggregation Activity of Black Sesame Pigment: Toward a Novel Alzheimer’s Disease Preventive Agent

1
Department of Chemical Sciences, University of Naples “Federico II”, Via Cintia 4, I-80126 Naples, Italy
2
School of Engineering and Environmental Sciences, Upper Austria University of Applied Sciences, Stelzhamerstraße 23, 4600 Wels, Austria
*
Author to whom correspondence should be addressed.
Received: 22 February 2018 / Revised: 14 March 2018 / Accepted: 15 March 2018 / Published: 16 March 2018
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Abstract

Black sesame pigment (BSP) represents a low cost, easily accessible material of plant origin exhibiting marked antioxidant and heavy metal-binding properties with potential as a food supplement. We report herein the inhibitory properties of the potentially bioaccessible fraction of BSP following simulated gastrointestinal digestion against key enzymes involved in Alzheimer’s disease (AD). HPLC analysis indicated that BSP is transformed under the pH conditions mimicking the intestinal environment and the most abundant of the released compounds was identified as vanillic acid. More than 80% inhibition of acetylcholinesterase-induced aggregation of the β-amyloid Aβ1-40 was observed in the presence of the potentially bioaccessible fraction of BSP, which also efficiently inhibited self-induced Aβ1-42 aggregation and β-secretase (BACE-1) activity, even at high dilution. These properties open new perspectives toward the use of BSP as an ingredient of functional food or as a food supplement for the prevention of AD. View Full-Text
Keywords: black sesame; Alzheimer’s disease; vanillic acid; simulated digestion; acetylcholinesterase; butyrylcholinesterase; β-amyloid; β-secretase black sesame; Alzheimer’s disease; vanillic acid; simulated digestion; acetylcholinesterase; butyrylcholinesterase; β-amyloid; β-secretase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Panzella, L.; Eidenberger, T.; Napolitano, A. Anti-Amyloid Aggregation Activity of Black Sesame Pigment: Toward a Novel Alzheimer’s Disease Preventive Agent. Molecules 2018, 23, 676.

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