Next Article in Journal
A Novel Approach for Microbial Synthesis of Enantiomerically Pure Whisky Lactones Based on Solid-State Fermentation
Previous Article in Journal
Hyperbranched Macromolecules: From Synthesis to Applications
Open AccessArticle

Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum

1
Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea
2
Department of Biosciences, Mokpo National University, Muan 58554, Korea
3
Department of Pharmacy, Graduate School, Sungkyunkwan University, Suwon 16419, Korea
4
Department of Polar Sciences, University of Science and Technology, Incheon 21990, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Molecules 2018, 23(3), 658; https://doi.org/10.3390/molecules23030658
Received: 20 February 2018 / Revised: 12 March 2018 / Accepted: 13 March 2018 / Published: 14 March 2018
(This article belongs to the Section Medicinal Chemistry)
Lobaric acid and lobarstin, secondary metabolites derived from the antarctic lichen Stereocaulon alpnum, exert various biological activities, including antitumor, anti-proliferation, anti-inflammation, and antioxidant activities. However, the underlying mechanisms of these effects have not yet been elucidated in human cervix adenocarcinoma and human colon carcinoma. In the present study, we evaluated the anticancer effects of lobaric acid and lobarstin on human cervix adenocarcinoma HeLa cells and colon carcinoma HCT116 cells. We show that the proliferation of Hela and HCT116 cells treated with lobaric acid and lobarstin significantly decreased in a dose- and time-dependent manner. Using flow cytometry analysis, we observed that the treatment with these compounds resulted in significant apoptosis in both cell lines, following cell cycle perturbation and arrest in G2/M phase. Furthermore, using immunoblot analysis, we investigated the expression of cell cycle and apoptosis-related marker genes and found a significant downregulation of the apoptosis regulator B-cell lymphoma 2 (Bcl-2) and upregulation of the cleaved form of the poly (ADP-ribose) polymerase (PARP), a DNA repair and apoptosis regulator. These results suggest that lobaric acid and lobarstin could significantly inhibit cell proliferation through cell cycle arrest and induction of apoptosis via the mitochondrial apoptotic pathway in cervix adenocarcinoma and colon carcinoma cells. Taken together, our data suggests that lobaric acid and lobarstin might be novel agents for clinical treatment of cervix adenocarcinoma and colon carcinoma. View Full-Text
Keywords: lobaric acid; lobarstin; antarctic lichen; apoptosis; cell cycle arrest; human cervix adenocarcinoma; human colon carcinoma lobaric acid; lobarstin; antarctic lichen; apoptosis; cell cycle arrest; human cervix adenocarcinoma; human colon carcinoma
Show Figures

Figure 1

MDPI and ACS Style

Hong, J.-M.; Suh, S.-S.; Kim, T.K.; Kim, J.E.; Han, S.J.; Youn, U.J.; Yim, J.H.; Kim, I.-C. Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum. Molecules 2018, 23, 658. https://doi.org/10.3390/molecules23030658

AMA Style

Hong J-M, Suh S-S, Kim TK, Kim JE, Han SJ, Youn UJ, Yim JH, Kim I-C. Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum. Molecules. 2018; 23(3):658. https://doi.org/10.3390/molecules23030658

Chicago/Turabian Style

Hong, Ju-Mi; Suh, Sung-Suk; Kim, Tai K.; Kim, Jung E.; Han, Se J.; Youn, Ui J.; Yim, Joung H.; Kim, Il-Chan. 2018. "Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum" Molecules 23, no. 3: 658. https://doi.org/10.3390/molecules23030658

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop