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Molecules 2018, 23(3), 654;

Recent Advances in Modified Cellulose for Tissue Culture Applications

Centre for Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK
Department of Chemistry, University of Bath, Bath BA2 7AY, UK
Department of Chemical Engineering, University of Bath, Bath BA2 7AY, UK
Author to whom correspondence should be addressed.
Received: 29 January 2018 / Revised: 9 March 2018 / Accepted: 12 March 2018 / Published: 14 March 2018
(This article belongs to the Special Issue Cellulose Chemical Modifications—Towards Sustainable Materials)
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Tissue engineering is a rapidly advancing field in regenerative medicine, with much research directed towards the production of new biomaterial scaffolds with tailored properties to generate functional tissue for specific applications. Recently, principles of sustainability, eco-efficiency and green chemistry have begun to guide the development of a new generation of materials, such as cellulose, as an alternative to conventional polymers based on conversion of fossil carbon (e.g., oil) and finding technologies to reduce the use of animal and human derived biomolecules (e.g., foetal bovine serum). Much of this focus on cellulose is due to it possessing the necessary properties for tissue engineering scaffolds, including biocompatibility, and the relative ease with which its characteristics can be tuned through chemical modification to adjust mechanical properties and to introduce various surface modifications. In addition, the sustainability of producing and manufacturing materials from cellulose, as well as its modest cost, makes cellulose an economically viable feedstock. This review focusses specifically on the use of modified cellulose materials for tissue culturing applications. We will investigate recent techniques used to promote scaffold function through physical, biochemical and chemical scaffold modifications, and describe how these have been utilised to reduce reliance on the addition of matrix ligands such as foetal bovine serum. View Full-Text
Keywords: tissue engineering; sustainable chemistry; cellulose; biomaterials; surface modifications; cell culturing; regenerative medicine tissue engineering; sustainable chemistry; cellulose; biomaterials; surface modifications; cell culturing; regenerative medicine

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Courtenay, J.C.; Sharma, R.I.; Scott, J.L. Recent Advances in Modified Cellulose for Tissue Culture Applications. Molecules 2018, 23, 654.

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