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Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species

1
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(2), 394; https://doi.org/10.3390/molecules23020394
Received: 7 January 2018 / Revised: 5 February 2018 / Accepted: 6 February 2018 / Published: 12 February 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro–S-Phe) (3) and cyclo(R-Pro–R-Phe) (4). The structures of compounds 14 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 24 displayed variable cytotoxic and antimicrobial activities. View Full-Text
Keywords: marine Penicillium sp.; 2,5-diketopiperazines; cytotoxic and antimicrobial activities marine Penicillium sp.; 2,5-diketopiperazines; cytotoxic and antimicrobial activities
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Youssef, D.T.A.; Alahdal, A.M. Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species. Molecules 2018, 23, 394.

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