Next Article in Journal
Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland
Previous Article in Journal
In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 23
Issue 2
10.3390/molecules23020258
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation

by
Abu Sadat Md Sayem
1,
Aditya Arya
2,*,
Hamed Karimian
2,
Narendiran Krishnasamy
3,
Ameya Ashok Hasamnis
2 and
Chowdhury Faiz Hossain
4
1
Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Department of Pharmacology and Therapeutics, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Lakeside Campus, 47500 Subang Jaya, Malaysia
3
Clinical Skills, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Lakeside Campus, 47500 Subang Jaya, Malaysia
4
Department of Pharmacy, Faculty of Sciences and Engineering, East West University, Dhaka-1212, Bangladesh
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(2), 258; https://doi.org/10.3390/molecules23020258
Submission received: 20 December 2017 / Revised: 15 January 2018 / Accepted: 23 January 2018 / Published: 28 January 2018
Browse Figures
Versions Notes

Abstract

Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate the rapid insulin-dependent storage of glucose in muscle and fat cells. Malfunction in glucose uptake mechanisms, primarily contribute to insulin resistance in type 2 diabetes. Plant secondary metabolites, commonly known as phytochemicals, are reported to have great benefits in the management of type 2 diabetes. The role of phytochemicals and their action on insulin signaling pathways through stimulation of GLUT4 translocation is crucial to understand the pathogenesis of this disease in the management process. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature.
Keywords: insulin receptor; insulin signaling pathways; PI3K; APS; GLUT4 translocation; phytochemicals insulin receptor; insulin signaling pathways; PI3K; APS; GLUT4 translocation; phytochemicals

Share and Cite

MDPI and ACS Style

Sayem, A.S.M.; Arya, A.; Karimian, H.; Krishnasamy, N.; Ashok Hasamnis, A.; Hossain, C.F. Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation. Molecules 2018, 23, 258. https://doi.org/10.3390/molecules23020258

AMA Style

Sayem ASM, Arya A, Karimian H, Krishnasamy N, Ashok Hasamnis A, Hossain CF. Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation. Molecules. 2018; 23(2):258. https://doi.org/10.3390/molecules23020258

Chicago/Turabian Style

Sayem, Abu Sadat Md, Aditya Arya, Hamed Karimian, Narendiran Krishnasamy, Ameya Ashok Hasamnis, and Chowdhury Faiz Hossain. 2018. "Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation" Molecules 23, no. 2: 258. https://doi.org/10.3390/molecules23020258

APA Style

Sayem, A. S. M., Arya, A., Karimian, H., Krishnasamy, N., Ashok Hasamnis, A., & Hossain, C. F. (2018). Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation. Molecules, 23(2), 258. https://doi.org/10.3390/molecules23020258

Article Metrics

Back to TopTop