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Synergic Activity Against MCF-7 Breast Cancer Cell Growth of Nanocurcumin-Encapsulated and Cisplatin-Complexed Nanogels

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Department of Pharmacy and Medicine, Tra Vinh University, Tra Vinh City 940000, Vietnam
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Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 1A TL29, District 12, Ho Chi Minh City 700000, Vietnam
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Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1A TL29, District 12, Ho Chi Minh City 700000, Vietnam
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Department of Natural Science, Thu Dau Mot University, Thu Dau Mot City 590000, Vietnam
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German Vietnamese Technology Center-HCMC University of Food Industry, Tan Phu District, Ho Chi Minh City 700000, Vietnam
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NTT Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ward 13, District 4, Ho Chi Minh City 700000, Vietnam
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University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3347; https://doi.org/10.3390/molecules23123347
Received: 29 October 2018 / Revised: 22 November 2018 / Accepted: 29 November 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Amphiphilic Polymers: Self-Assembly and Applications)
Nanogel-based systems loaded with single anticancer drugs display miscellaneous effectiveness in tumor remission, gradually circumventing mutation and resistance in chemotherapy. Hence, the existence of dual-drug delivered nano-sized systems has been contemporaneous with drug development and preceded the conventional-dose chemotherapy. Among outstanding synergistic drug nanoplatforms, thermosensitive copolymer heparin-Pluronic F127 (Hep-F127) co-delivering cisplatin (CDDP) and curcumins (Cur) (Hep-F127/CDDP/Cur) has emerged as a notable candidate for temperature-responsive drug delivery. The procedure was based on the entrapment of curcumin into the hydrophobic core of bio-degradable co-polymer Hep-F127 while the hydrophilic drug CDDP subsequently conjugated to the backbone heparin to form the core-shell structure. The copolymer was characterized by Fourier transform infrared (FT-IR) spectrophotometry, Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS), to corroborate the successful synthesis and via HPLC along with AES-ICP to evaluate the high drug loading along with a controllable release from the nano-gels. A well-defined nano-shell with size in the 129.3 ± 3.8 nm size range could enhance higher the efficacy of the conjugated-CDDP to Hep-F127 than that of single doses. Moreover, the considerable amount of dual-drug released from thermosensitive nanogels between different conditions (pH = 7.4 and pH = 5.5) in comparison to CDDP from Hep-F127 partially indicated the significantly anti-proliferative ability of Hep-F127/CDDP/Cur to the MCF-7 cell line. Remarkably, drug testing in a xenograft model elucidates the intricate synergism of co-delivery in suppressing tumor growth, which remedies some of the problems affecting in cancer chemotherapy. View Full-Text
Keywords: dual drugs; delivery; nanocarriers; cisplatin; nanocurcumin dual drugs; delivery; nanocarriers; cisplatin; nanocurcumin
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Nguyen, N.T.; Nguyen, N.N.T.; Tran, N.T.N.; Le, P.N.; Nguyen, T.B.T.; Nguyen, N.H.; Bach, L.G.; Doan, V.N.; Tran, H.L.B.; Le, V.T.; Tran, N.Q. Synergic Activity Against MCF-7 Breast Cancer Cell Growth of Nanocurcumin-Encapsulated and Cisplatin-Complexed Nanogels. Molecules 2018, 23, 3347.

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