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Open AccessReview

Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Beijing Body Revival Medical Technology Co., Ltd., Beijing 100088, China
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3280;
Received: 7 November 2018 / Revised: 5 December 2018 / Accepted: 6 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Application of Novel Method in Pharmaceutical Study)
Objective: We summarized the progress of the xCELLigence real-time cell analysis (RTCA) technology application in recent years for the sake of enriching and developing the application of RTCA in the field of Chinese medicine. Background: The RTCA system is an established electronic cellular biosensor. This system uses micro-electronic biosensor technology that is confirmed for real-time, label-free, dynamic and non-offensive monitoring of cell viability, migration, growth, spreading, and proliferation. Methods: We summarized the relevant experiments and literature of RTCA technology from the principles, characteristics, applications, especially from the latest application progress. Results and conclusion: RTCA is attracting more and more attention. Now it plays an important role in drug screening, toxicology, Chinese herbal medicine and so on. It has wide application prospects in the area of modern pharmaceutical evaluation and analysis. View Full-Text
Keywords: RTCA; application progress; traditional Chinese medicine; pharmaceutical evaluation RTCA; application progress; traditional Chinese medicine; pharmaceutical evaluation
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MDPI and ACS Style

Yan, G.; Du, Q.; Wei, X.; Miozzi, J.; Kang, C.; Wang, J.; Han, X.; Pan, J.; Xie, H.; Chen, J.; Zhang, W. Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis. Molecules 2018, 23, 3280.

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