Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian Eryngium campestre
AbstractThe chemical composition of a hexanic extract of Eryngium campestre, obtained from its aerial parts, was investigated by GC-FID, GC/MS, HRMS, NMR and VCD analyses. The main compounds were germacrene D (23.6%), eudesma-4(15)-7-dien-1-β-ol (8.2%) and falcarindiol (9.4%), which are associated with a new uncommon and naturally found 17-membered ring lactone. This 17-membered ring features conjugated acetylenic bonds, named campestrolide (23.0%). The crude extract showed moderate antitrypanosomal (Trypanosoma brucei brucei), antileishmanial (Leishmania mexicana mexicana) and anticancer (cancerous macrophage-like murine cells) activities, and also displayed cytotoxicity, (human normal fibroblasts) in similar concentration ranges (IC50 = 3.0, 3.9, 4.0 and 4.4 µg/mL respectively). Likewise, campestrolide displayed low activity on all tested cells (IC50: 12.5–19.5 µM) except on Trypanosoma, on which it was very active and moderately selective (IC50 = 2.2 µM. SI= 8.9). In conclusion, the new compound that has been described, displaying a singular structure, possesses interesting antitrypanosomal activity that should be further investigated and improved. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 1308 KB)
Share & Cite This Article
Medbouhi, A.; Tintaru, A.; Beaufay, C.; Naubron, J.-V.; Djabou, N.; Costa, J.; Quetin-Leclercq, J.; Muselli, A. Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian Eryngium campestre. Molecules 2018, 23, 3250.
Medbouhi A, Tintaru A, Beaufay C, Naubron J-V, Djabou N, Costa J, Quetin-Leclercq J, Muselli A. Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian Eryngium campestre. Molecules. 2018; 23(12):3250.Chicago/Turabian Style
Medbouhi, Ali; Tintaru, Aura; Beaufay, Claire; Naubron, Jean-Valère; Djabou, Nassim; Costa, Jean; Quetin-Leclercq, Joëlle; Muselli, Alain. 2018. "Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian Eryngium campestre." Molecules 23, no. 12: 3250.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.