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Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin

University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining 835000, China
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Author to whom correspondence should be addressed.
Academic Editors: David Barker and Derek J. McPhee
Molecules 2018, 23(11), 3037;
Received: 30 October 2018 / Revised: 12 November 2018 / Accepted: 17 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Lignans)
PDF [1343 KB, uploaded 21 November 2018]


Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group. View Full-Text
Keywords: aryldihydronaphthalene lignan; arylnaphthalene lignan; oxidation; synthesis aryldihydronaphthalene lignan; arylnaphthalene lignan; oxidation; synthesis

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Xiao, J.; Nan, G.; Wang, Y.-W.; Peng, Y. Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin. Molecules 2018, 23, 3037.

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