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Molecules 2018, 23(11), 2914;

Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Department of Medicinal Chemistry and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
School of Public Health, Qingdao University, Qingdao 266021, China
Author to whom correspondence should be addressed.
Received: 18 October 2018 / Revised: 4 November 2018 / Accepted: 5 November 2018 / Published: 8 November 2018
PDF [1826 KB, uploaded 8 November 2018]


Diterpenoids are widely distributed natural products and have caused considerable interest because of their unique skeletons and antibacterial and antitumor activities and so on. In light of recent discoveries, ent-kaurane diterpenoids, which exhibit a wide variety of biological activities, such as anticancer and anti-inflammatory activities, pose enormous potential to serve as a promising candidate for drug development. Among them, spirolactone-type 6,7-seco-ent-kaurane diterpenoids, with interesting molecular skeleton, complex oxidation patterns, and bond formation, exhibit attractive activities. Furthermore, spirolactone-type diterpenoids have many modifiable sites, which allows for linking to various substituents, suitable for further medicinal study. Hence, some structurally modified derivatives with improved cytotoxicity activities are also achieved. In this review, natural bioactive spirolactone-type diterpenoids and their synthetic derivatives were summarized. View Full-Text
Keywords: spirolactone-type; 6,7-seco-ent-kaurane; diterpenoid; natural product; synthetic derivative spirolactone-type; 6,7-seco-ent-kaurane; diterpenoid; natural product; synthetic derivative

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Li, H.; Jiao, R.; Mu, J.; Xu, S.; Li, X.; Wang, X.; Li, Z.; Xu, J.; Hua, H.; Li, D. Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives. Molecules 2018, 23, 2914.

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