New Metabolites from Endophytic Fungus Chaetomium globosum CDW7
AbstractFive metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3–5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%). View Full-Text
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Yan, W.; Cao, L.-L.; Zhang, Y.-Y.; Zhao, R.; Zhao, S.-S.; Khan, B.; Ye, Y.-H. New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. Molecules 2018, 23, 2873.
Yan W, Cao L-L, Zhang Y-Y, Zhao R, Zhao S-S, Khan B, Ye Y-H. New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. Molecules. 2018; 23(11):2873.Chicago/Turabian Style
Yan, Wei; Cao, Ling-Ling; Zhang, Yang-Yang; Zhao, Ran; Zhao, Shuang-Shuang; Khan, Babar; Ye, Yong-Hao. 2018. "New Metabolites from Endophytic Fungus Chaetomium globosum CDW7." Molecules 23, no. 11: 2873.
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