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Molecules 2018, 23(11), 2873;

New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China
These authors contributed equally to this paper.
Author to whom correspondence should be addressed.
Received: 10 October 2018 / Revised: 26 October 2018 / Accepted: 1 November 2018 / Published: 4 November 2018
(This article belongs to the Section Natural Products Chemistry)
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Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 35 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%). View Full-Text
Keywords: Chaetomium globosum; isocoumarin derivatives; indole alkaloid; antifungal activity Chaetomium globosum; isocoumarin derivatives; indole alkaloid; antifungal activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yan, W.; Cao, L.-L.; Zhang, Y.-Y.; Zhao, R.; Zhao, S.-S.; Khan, B.; Ye, Y.-H. New Metabolites from Endophytic Fungus Chaetomium globosum CDW7. Molecules 2018, 23, 2873.

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