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Molecules 2018, 23(11), 2806;

Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy

Laboratory of Toxicology, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
College Department of Oral Pathology, School of Dentistry, Chonbuk National University, Jeonju 54896, Korea
Korea Institute of Oriental Medicine, Daejeon 34054, Korea
Author to whom correspondence should be addressed.
Academic Editors: Chiara Tonelli and Katia Petroni
Received: 28 September 2018 / Revised: 19 October 2018 / Accepted: 29 October 2018 / Published: 29 October 2018
(This article belongs to the Special Issue Plant Bioactives in Preventing Chronic Diseases)
PDF [2589 KB, uploaded 30 October 2018]


Swelling of retinal Müller cells is implicated in retinal edema and neuronal degeneration. Müller cell swelling is observed in patients with liver failure and is referred to as hepatic retinopathy. In the present study, we evaluated the effects of aloin, an anthraquinone-C-glycoside present in various Aloe species, on Müller cell dysfunction in a rat model of thioacetamide (TAA)-induced hepatic retinopathy. Experimental hepatic retinopathy was induced by three injections of TAA (200 mg/kg/day, intraperitoneal injection) for 3 days in rats. After the last injection of TAA, aloin (50 and 100 mg/kg) was orally gavaged for 5 days. The effects of aloin on the liver injury, serum ammonia levels, Müller cell swelling, glial fibrillary acidic protein (GFAP) expression, and gene expression of Kir4.1 and aquaporin-4 were examined. TAA-injected rats exhibited liver failure and hyperammonemia. In the TAA-injected rats, Müller cell bodies were highly enlarged, and GFAP, an indicator of retinal stress, was highly expressed in the retinas, indicating a predominant Müller cell gliosis. However, administration of aloin suppressed liver injury as well as Müller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Müller cells. These results indicate that aloin may be helpful to protect retinal injury associated with liver failure. View Full-Text
Keywords: aloin; hepatic retinopathy; Müller cell; swelling aloin; hepatic retinopathy; Müller cell; swelling

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Jung, E.; Kim, J. Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy. Molecules 2018, 23, 2806.

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