Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics
Abstract
:1. Introduction
2. Polyphenol-Loaded Polymeric Nanotherapeutics for Cancer Treatment
2.1. Polymer-Based Nanovesicles
2.2. Polymer-Based Nanoparticles
2.3. Polymer-Based Conjugates
2.4. Carbon-Based Nanostructures and Nanohybrids
2.5. Magnetic Nanoparticles Manipulation of Nanoparticles Using Magnetic Field
3. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Cirillo, G.; Curcio, M.; Vittorio, O.; Lemma, F.; Restuccia, D.; Spizzirri, U.G.; Puoci, F.; Picci, N. Polyphenol conjugates and human health: A perspective review. Crit. Rev. Food Sci. Nutr. 2016, 56, 326–337. [Google Scholar] [CrossRef] [PubMed]
- Nichenametla, S.N.; Taruscio, T.G.; Barney, D.L.; Exon, J.H. A review of the effects and mechanisms of polyphenolics in cancer. Crit. Rev. Food Sci. Nutr. 2006, 46, 161–183. [Google Scholar] [CrossRef] [PubMed]
- Del Rio, D.; Rodriguez-Mateos, A.; Spencer, J.P.E.; Tognolini, M.; Borges, G.; Crozier, A. Dietary polyphenolics in human health, structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox. Signal 2013, 18, 1818–1892. [Google Scholar] [CrossRef] [PubMed]
- Williams, R.J.; Spencer, J.P.E.; Rice-Evans, C. Flavonoids, antioxidants or signalling molecules? Free. Radic. Biol. Med. 2004, 36, 838–849. [Google Scholar] [CrossRef] [PubMed]
- Yao, L.H.; Jiang, Y.M.; Shi, J.; Tomás-Barberán, F.A.; Datta, N.; Singanusong, R.; Chen, S.S. Flavonoids in food and their health benefits. Plant Foods Hum. Nutr. 2004, 59, 113–122. [Google Scholar] [CrossRef] [PubMed]
- Spencer, J.P.E.; Schroeter, H.; Crossthwaithe, A.J.; Kuhnle, G.; Williams, R.J.; Rice-Evans, C. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free. Radic. Biol. Med. 2001, 31, 1139–1146. [Google Scholar] [CrossRef]
- Kong, A.N.T.; Yu, R.; Chen, C.; Mandlekar, S.; Primiano, T. Signal transduction events elicited by natural products, role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharmacal. Res. 2000, 23, 1–16. [Google Scholar] [CrossRef]
- Luo, Y.; Prestwich, G.D. Cancer-targeted polymeric drugs. Curr. Cancer Drug Targets 2002, 2, 209–226. [Google Scholar] [CrossRef] [PubMed]
- Luo, J.; Solimini, N.L.; Elledge, S.J. Principles of cancer therapy, oncogene and non-oncogene addiction. Cell 2009, 136, 823–837. [Google Scholar] [CrossRef] [PubMed]
- Jemal, A.; Siegel, R.; Xu, J.; Ward, E. Cancer statistics, 2010. CA Cancer J. Clin. 2010, 60, 277–300. [Google Scholar] [CrossRef] [PubMed]
- Gharpure, K.M.; Wu, S.Y.; Li, C.; Lopez-Berestein, G.; Sood, A.K. Nanotechnology, future of oncotherapy. Clin. Cancer Res. 2015, 21, 3121–3130. [Google Scholar] [CrossRef] [PubMed]
- Pacardo, D.B.; Ligler, F.S.; Gu, Z. Programmable nanomedicine, synergistic and sequential drug delivery systems. Nanoscale 2015, 7, 3381–3391. [Google Scholar] [CrossRef] [PubMed]
- Stylianopoulos, T.; Jain, R.K. Design considerations for nanotherapeutics in oncology. Nanomed. Nanotechnol. Biol. Med. 2015, 11, 1893–1907. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Eetezadi, S.; Ekdawi, S.N.; Allen, C. The challenges facing block copolymer micelles for cancer therapy, in vivo barriers and clinical translation. Adv. Drug Deliv. Rev. 2015, 91, 7–22. [Google Scholar] [CrossRef] [PubMed]
- Fernandes, E.; Ferreira, J.A.; Andreia, P.; Luís, L.; Barroso, S.; Sarmento, B.; Santos, L.L. New trends in guided nanotherapies for digestive cancers, a systematic review. J. Control Release 2015, 209, 288–307. [Google Scholar] [CrossRef] [PubMed]
- Johnstone, T.C.; Suntharalingam, K.; Lippard, S.J. The next generation of platinum drugs, targeted PtII agents, nanoparticle delivery, and PtIV prodrugs. Chem. Rev. 2016, 116, 3436–3486. [Google Scholar] [CrossRef] [PubMed]
- Kumari, P.; Ghosh, B.; Biswas, S. Nanocarriers for cancer-targeted drug delivery. J. Drug Target 2016, 24, 179–191. [Google Scholar] [CrossRef] [PubMed]
- Siddiqui, I.A.; Adhami, V.M.; Chamcheu, C.J.; Mukhtar, H. Impact of nanotechnology in cancer, emphasis on nanochemoprevention. Int. J. Nanomed. 2012, 7, 591–605. [Google Scholar]
- Brinkhuis, R.P.; Rutjes, F.P.J.T.; Van Hest, J.C.M. Polymeric vesicles in biomedical applications. Polym. Chem. 2011, 2, 1449–1462. [Google Scholar] [CrossRef]
- Discher, B.M.; Hammer, D.A.; Bates, F.S.; Discher, D.E. Polymer vesicles in various media. Curr. Opin. Colloid Interface Sci. 2000, 5, 125–131. [Google Scholar] [CrossRef]
- Onaca, O.; Enea, R.; Hughes, D.W.; Meier, W. Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol. Biosci. 2009, 9, 129–139. [Google Scholar] [CrossRef] [PubMed]
- Broz, P.; Benito, S.M.; Saw, C.; Burger, P.; Heider, H.; Pfisterer, M.; Marsch, S.; Meier, W.; Hunziker, P. Cell targeting by a generic receptor-targeted polymer nanocontainer platform. J. Control. Release 2005, 102, 475–488. [Google Scholar] [CrossRef] [PubMed]
- Tong, R.; Cheng, J. Anticancer polymeric nanomedicines. Polym. Rev. 2007, 345–381. [Google Scholar] [CrossRef]
- Torchilin, V.P. Micellar nanocarriers, pharmaceutical perspectives. Pharm. Res. 2007, 24, 1–16. [Google Scholar] [CrossRef] [PubMed]
- Lu, Y.; Park, K. Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. Int. J. Pharm. 2013, 453, 198–214. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhou, H.; Sun, X.; Zhang, L.; Zhang, P.; Li, J.; Liu, Y.N. Fabrication of biopolymeric complex coacervation core micelles for efficient tea polyphenol delivery via a green process. Langmuir 2012, 28, 14553–14561. [Google Scholar] [CrossRef] [PubMed]
- Zhang, L.; Qi, Z.; Huang, Q.; Zeng, K.; Sun, X.; Li, J.; Liu, Y.N. Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery. Colloids Surf. B Biointerfaces 2014, 123, 15–22. [Google Scholar] [CrossRef] [PubMed]
- Wang, G.; Wang, J.J.; To, T.S.S.; Zhao, H.F.; Wang, J. Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes. Int. J. Nanomed. 2015, 10, 5005–5023. [Google Scholar]
- Curcio, M.; Blanco-Fernandez, B.; Diaz-Gomez, L.; Concheiro, A.; Alvarez-Lorenzo, C. Hydrophobically modified keratin vesicles for GSH-responsive intracellular drug release. Bioconjug. Chem. 2015, 26, 1900–1907. [Google Scholar] [CrossRef] [PubMed]
- Curcio, M.; Cirillo, G.; Vittorio, O.; Umile, G.S.; Francesca, L.; Nevio, P. Hydrolyzed gelatin-based polymersomes as delivery devices of anticancer drugs. Eur. Polym. J. 2015, 67, 304–313. [Google Scholar] [CrossRef]
- Cote, B.; Carlson, L.J.; Rao, D.A.; Alani, A.W.G. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. J. Control Release 2015, 213, 128–133. [Google Scholar] [CrossRef] [PubMed]
- Sahu, A.; Kasoju, N.; Bora, U. Fluorescence study of the curcumincasein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules 2008, 9, 2905–2912. [Google Scholar] [CrossRef] [PubMed]
- Podaralla, S.; Averineni, R.; Alqahtani, M.; Perumal, O. Synthesis of novel biodegradable methoxy polyethylene glycol-zein micelles for effective delivery of curcumin. Mol. Pharm. 2012, 9, 2778–2786. [Google Scholar] [CrossRef] [PubMed]
- Wang, K.; Zhang, T.; Liu, L.; Wang, X.; Wu, P.; Chen, Z.; Ni, C.; Zhang, J.; Hu, F.; Huang, J. Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells. Int. J. Nanomed. 2012, 7, 4487–4497. [Google Scholar] [Green Version]
- Lv, L.; Shen, Y.; Li, M.; Xu, X.; Li, M.; Guo, S.; Huang, S. Novel 4-arm polyethylene glycolblock-polyanhydride-esters amphiphilic copolymer micelles loading curcumin, preparation, characterization, and in vitro evaluation. BioMed. Res. Int. 2013, 2013. [Google Scholar] [CrossRef] [PubMed]
- Lv, L.; Qiu, K.; Yu, X.; Chen, C.; Qin, F.; Shi, Y.; Ou, J.; Zhang, T.; Zhu, H.; Wu, J.; et al. Amphiphilic copolymeric micelles for doxorubicin and curcumin co-delivery to reverse multidrug resistance in breast cancer. J. Biomed. Nanotechnol. 2016, 12, 973–985. [Google Scholar] [CrossRef] [PubMed]
- Zhu, W.; Song, Z.; Wei, P.; Meng, N.; Teng, F.; Yang, F.; Liu, N.; Feng, R. Y-shaped biotinconjugated poly ethylene glycol-poly epsilon-caprolactone copolymer for the targeted delivery of curcumin. J. Colloid Interface Sci. 2015, 443, 1–7. [Google Scholar] [CrossRef] [PubMed]
- Gou, Q.; Liu, L.; Wang, C.; Wu, Q.; Sun, L.; Yang, X.; Xie, Y.; Li, P.; Gong, C. Polymeric nanoassemblies entrapping curcumin overcome multidrug resistance in ovarian cancer. Colloids Surf. B Biointerfaces 2015, 126, 26–34. [Google Scholar] [CrossRef] [PubMed]
- Mikhail, A.S.; Eetezadi, S.; Ekdawi, S.N.; Stewart, J.; Allen, C. Image-based analysis of the size-and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts. Int. J. Pharm. 2014, 464, 168–177. [Google Scholar] [CrossRef] [PubMed]
- Liu, L.; Sun, L.; Wu, Q.; Guo, W.; Li, L.; Chen, Y.; Li, Y.; Gong, C.; Qian, Z.; Wei, Y. Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis. Int. J. Pharm. 2013, 443, 175–182. [Google Scholar] [CrossRef] [PubMed]
- Wang, B.L.; Shen, Y.M.; Zhang, Q.W.; Li, Y.L.; Luo, M.; Liu, Z.; Li, Y.; Qian, Z.Y.; Gao, X.; Shi, H.S. Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer. Int. J. Nanomed. 2013, 8, 3521–3531. [Google Scholar] [Green Version]
- Erfani-Moghadam, V.; Nomani, A.; Zamani, M.; Yazdani, Y.; Najafi, F.; Sadeghizadeh, M. A novel diblock copolymer of monomethoxy poly [ethylene glycol]-oleate with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells. Int. J. Nanomed. 2014, 9, 5541–5554. [Google Scholar] [CrossRef] [PubMed]
- Song, Z.; Zhu, W.; Liu, N.; Yang, F.; Feng, R. Linolenic acid-modified PEG-PCL micelles for curcumin delivery. Int. J. Pharm. 2014, 471, 312–321. [Google Scholar] [CrossRef] [PubMed]
- Abouzeid, A.H.; Patel, N.R.; Rachman, I.M.; Senn, S.; Torchilin, V.P. Anti-cancer activity of anti-GLUT1 antibody-targeted polymeric micelles co-loaded with curcumin and doxorubicin. J. Drug Target 2013, 21, 994–1000. [Google Scholar] [CrossRef] [PubMed]
- Abouzeid, A.H.; Patel, N.R.; Sarisozen, C.; Torchilin, V.P. Transferrin targeted polymeric micelles co-loaded with curcumin and paclitaxel, efficient killing of paclitaxel-resistant cancer cells. Pharm. Res. 2014, 31, 1938–1945. [Google Scholar] [CrossRef] [PubMed]
- Sarisozen, C.; Abouzeid, A.H.; Torchilin, V.P. The effect of codelivery of paclitaxel and curcumin by transferrin-targeted PEG-PEbased mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors. Eur. J. Pharm. Biopharm. 2014, 88, 539–550. [Google Scholar] [CrossRef] [PubMed]
- Zhang, Y.; Yang, C.; Wang, W.; Liu, J.; Liu, Q.; Huang, F.; Chu, L.; Gao, H.; Li, C.; Kong, D.; et al. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer. Sci. Rep. 2016, 6, 21225. [Google Scholar] [CrossRef] [PubMed]
- Sahu, A.; Kasoju, N.; Goswami, P.; Bora, U. Encapsulation of curcumin in Pluronic block copolymer micelles for drug delivery applications. J. Biomater. Appl. 2011, 25, 619–639. [Google Scholar] [CrossRef] [PubMed]
- Saxena, V.; Hussain, M.D. Polymeric mixed micelles for delivery of curcumin to multidrug resistant ovarian cancer. J. Biomed. Nanotechnol. 2013, 9, 1146–1154. [Google Scholar] [CrossRef] [PubMed]
- Carlson, L.J.; Cote, B.; Alani, A.W.; Rao, D.A. Polymeric micellar codelivery of resveratrol and curcumin to mitigate in vitro doxorubicin induced cardiotoxicity. J. Pharm. Sci. 2014, 103, 2315–2322. [Google Scholar] [CrossRef] [PubMed]
- Kim, S.H.; Adhikari, B.B.; Cruz, S.; Schramm, M.P.; Vinson, J.A.; Narayanaswami, V. Targeted intracellular delivery of resveratrol to glioblastoma cells using apolipoprotein E-containing reconstituted HDL as a nanovehicle. PLoS ONE 2015, 10, e013. [Google Scholar] [CrossRef] [PubMed]
- Wang, S.; Chen, R.; Morott, J.; Repka, M.A.; Wang, Y.; Chen, M. MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opin. Drug Deliv. 2015, 12, 361–373. [Google Scholar] [CrossRef] [PubMed]
- Haratifar, S.; Meckling, K.A.; Corredig, M. Antiproliferative activity of tea catechins associated with casein micelles, using HT29 colon cancer cells. J. Dairy Sci. 2014, 97, 672–678. [Google Scholar] [CrossRef] [PubMed]
- Sun, L.; Zhang, C.; Li, P. Copolymeric micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells. Nutr. Cancer 2014, 66, 896–903. [Google Scholar] [CrossRef] [PubMed]
- Hu, C.M.J.; Aryal, S.; Zhang, L. Nanoparticle-assisted combination therapies for effective cancer treatment. Ther. Deliv. 2010, 1, 323–334. [Google Scholar] [CrossRef] [PubMed]
- Pe´rez-Herrero, E.; Ferna´ndez-Medarde, A. Advanced targeted therapies in cancer, drug nanocarriers, the future of chemotherapy. Eur. J. Pharm. Biopharm. 2015, 93, 52–79. [Google Scholar] [CrossRef] [PubMed]
- Tsouris, V.; Joo, M.K.; Kim, S.H.; Kwon, I.C.; Won, Y.Y. Nanocarriers that enable codelivery of chemotherapy and RNAi agents for treatment of drugresistant cancers. Biotechnol. Adv. 2014, 32, 1037–1050. [Google Scholar] [CrossRef] [PubMed]
- Estanqueiro, M.; Amaral, M.H.; Conceicao, J.; Sousa Lobo, J.M. Nanotechnological carriers for cancer chemotherapy, the state of the art. Colloids Surf. B Biointerfaces 2015, 126, 631–648. [Google Scholar] [CrossRef] [PubMed]
- Danhier, F.; Ansorena, E.; Silva, J.M.; Coco, R.; Le Breton, A.; Préat, V. PLGA-based nanoparticles, an overview of biomedical applications. J. Control Release 2012, 161, 505–522. [Google Scholar] [CrossRef] [PubMed]
- Dong, H.; Tang, M.; Li, Y.; Li, Y.; Qian, D.; Shi, D. Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery. Nanomedicine 2015, 10, 1941–1958. [Google Scholar] [CrossRef] [PubMed]
- Shirode, A.B.; Bharali, D.J.; Nallanthighal, S.; Coon, J.K.; Mousa, S.A.; Reliene, R. Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention. Int. J. Nanomed 2015, 10, 475–484. [Google Scholar]
- Liang, J.; Li, F.; Fang, Y.; Yang, W.; An, X.; Zhao, L.; Xin, Z.; Cao, L.; Hu, Q. Cytotoxicity and apoptotic effects of tea polyphenol-loaded chitosan nanoparticles on human hepatoma HepG2 cells. Mater. Sci. Eng. C 2014, 36, 7–13. [Google Scholar] [CrossRef] [PubMed]
- Kim, Y.J.; Park, M.R.; Kim, M.S.; Kwon, O.H. Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells. Mater. Chem. Phys. 2012, 133, 674–680. [Google Scholar] [CrossRef]
- Das, R.K.; Kasoju, N.; Bora, U. Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomed. Nanotechnol. Biol. Med. 2010, 6, e15360. [Google Scholar]
- Sanoj Rejinold, N.; Muthunarayanan, M.; Chennazhi, K.P.; Nair, S.V.; Jayakumar, R. Curcumin loaded fibrinogen nanoparticles for cancer drug delivery. J. Biomed. Nanotechnol. 2011, 7, 521–534. [Google Scholar] [CrossRef]
- Peng, S.F.; Lee, C.Y.; Hour, M.J.; Tsai, S.C.; Kuo, D.H.; Chen, F.A.; Shieh, P.C.; Yang, J.S. Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. Int. J. Oncol. 2014, 44, 238–246. [Google Scholar] [CrossRef] [PubMed]
- Mangalathillam, S.; Rejinold, N.S.; Nair, A.; Lakshmanan, V.K.; Nair, S.V.; Jayakumar, R. Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route. Nanoscale 2012, 4, 239–250. [Google Scholar] [CrossRef] [PubMed]
- Altunbas, A.; Lee, S.J.; Rajasekaran, S.A.; Schneider, J.P.; Pochan, D.J. Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. Biomaterials 2011, 32, 5906–5914. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bisht, S.; Feldmann, G.; Soni, S.; Ravi, R.; Karikar, C.; Maitra, A.; Maitra, A. Polymeric nanoparticleencapsulated curcumin ‘‘nanocurcumin’’, a novel strategy for human cancer therapy. J. Nanobiotechnol. 2007, 5, 3. [Google Scholar] [CrossRef] [PubMed]
- Li, L.; Xiang, D.; Shigdar, S.; Yang, W.; Li, Q.; Lin, J.; Liu, K.; Duan, W. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int. J. Nanomed. 2014, 9, 1083–1096. [Google Scholar]
- Yallapu, M.M.; Gupta, B.K.; Jaggi, M.; Chauhan, S.C. Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J. Colloid Interface Sci. 2010, 351, 19–29. [Google Scholar] [CrossRef] [PubMed]
- Yallapu, M.M.; Dobberpuhl, M.R.; Maher, D.M.; Jaggi, M.; Chauhan, S.C. Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr. Drug Metab. 2012, 13, 120–128. [Google Scholar] [CrossRef] [PubMed]
- Yallapu, M.M.; Khan, S.; Maher, D.M.; Ebeling, M.C.; Sundram, V.; Chauhan, N.; Ganju, A.; Balakrishna, S.; Gupta, B.K.; Zafar, N.; et al. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials 2014, 35, 8635–8648. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kim, T.H.; Jiang, H.H.; Youn, Y.S.; Park, C.W.; Tak, K.K.; Lee, S.; Kim, H.; Jon, S.; Chen, X.; Lee, K.C. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int. J. Pharm. 2011, 403, 285–291. [Google Scholar] [CrossRef] [PubMed]
- Madhusudana Rao, K.; Krishna Rao, K.S.; Ramanjaneyulu, G.; Ha, C.S. Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anticancer drug delivery. Int. J. Pharm. 2015, 478, 788–795. [Google Scholar] [CrossRef] [PubMed]
- Montalbán, M.G.; Coburn, J.M.; Lozano-Pérez, A.A.; Cenis, J.L.; Víllora, G.; Kaplan, D.L. Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy. Nanomaterials 2018, 8, 26. [Google Scholar] [CrossRef] [PubMed]
- Duan, J.; Mansour, H.M.; Zhang, Y.; Deng, X.; Chen, Y.; Wang, J.; Pan, Y.; Zhao, J. Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/polybutyl cyanoacrylate nanoparticles. Int. J. Pharm. 2012, 426, 193–201. [Google Scholar] [CrossRef] [PubMed]
- Balasubramanian, S.; Ravindran Girija, A.; Nagaoka, Y.; Iwai, S.; Suzuki, M.; Kizhikkilot, V.; Yoshida, Y.; Maekawa, T.; Nair, S.D. Curcumin and 5-Fluorouracil-loaded, folate-and transferrin-decorated polymeric magnetic nanoformulation, a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. Int. J. Nanomed. 2014, 9, 437–459. [Google Scholar]
- Yallapu, M.M.; Maher, D.M.; Sundram, V.; Bell, M.C.; Jaggi, M.; Chauhan, S.C. Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J. Ovarian. Res. 2010, 3, 11. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bisht, S.; Mizuma, M.; Feldmann, G.; Ottenhof, N.A.; Hong, S.M.; Pramanik, D.; Chenna, V.; Karikari, C.; Sharma, R.; Goggins, M.G.; et al. Systemic administration of polymeric nanoparticle-encapsulated curcumin NanoCurc blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol. Cancer Ther. 2010, 9, 2255–2264. [Google Scholar] [CrossRef] [PubMed]
- Shutava, T.G.; Balkundi, S.S.; Vangala, P. Layer-by-layercoated gelatin nanoparticles as a vehicle for delivery of natural polyphenols. ACS Nano 2009, 3, 1877–1885. [Google Scholar] [CrossRef] [PubMed]
- Sanna, V.; Pintus, G.; Roggio, A.M. Targeted biocompatible nanoparticles for the delivery of -epigallocatechin 3-gallate to prostate cancer cells. J. Med. Chem. 2011, 54, 1321–1332. [Google Scholar] [CrossRef] [PubMed]
- Hu, B.; Xie, M.; Zhang, C.; Zeng, X. Genipin-structured peptide-polysaccharide nanoparticles with significantly improved resistance to harsh gastrointestinal environments and their potential for oral delivery of polyphenols. J. Agric. Food Chem. 2014, 62, 12443–12452. [Google Scholar] [CrossRef] [PubMed]
- Hu, B.; Wang, Y.; Xie, M.; Guanlan, H.; Fengguang, A.; Xiaoxiong, Z. Polymer nanoparticles composed with gallic acid grafted chitosan and bioactive peptides combined antioxidant, anticancer activities and improved delivery property for labile polyphenols. J. Funct. Foods 2015, 15, 593–603. [Google Scholar] [CrossRef]
- Ray, L.; Kumar, P.; Gupta, K.C. The activity against Ehrlich’s ascites tumors of doxorubicin contained in self assembled, cell receptor targeted nanoparticle with simultaneous oral delivery of the green tea polyphenol epigallocatechin-3-gallate. Biomaterials 2013, 34, 3064–3076. [Google Scholar] [CrossRef] [PubMed]
- Lin, Y.H.; Chen, Z.R.; Lai, C.H.; Hsieh, C.H.; Feng, C.L. Active targeted nanoparticles for oral administration of gastric cancer therapy. Biomacromolecules 2015, 16, 3021–3032. [Google Scholar] [CrossRef] [PubMed]
- Khan, N.; Bharali, D.J.; Adhami, V.M.; Siddiqui, I.A.; Cui, H.; Shabana, S.M.; Mousa, S.A.; Mukhtar, H. Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis 2014, 35, 415–423. [Google Scholar] [CrossRef] [PubMed]
- Siddiqui, I.A.; Bharali, D.J.; Nihal, M.; Adhami, V.M.; Khan, N.; Chamcheu, J.C.; Khan, M.I.; Shabana, S.; Mousa, S.A.; Mukhtar, H. Excellent antiproliferative and pro-apoptotic effects of -epigallocatechin-3gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomed Nanotechnol. Biol. Med. 2014, 10, 1619–1626. [Google Scholar] [CrossRef] [PubMed]
- Singh, M.; Bhatnagar, P.; Srivastava, A.K.; Kumar, P.; Shukla, Y.; Gupta, K.C. Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols polylactide-co-glycolide nanoparticles. J. Biomed. Nanotechnol. 2011, 7, 202. [Google Scholar] [CrossRef] [PubMed]
- Singh, M.; Bhatnagar, P.; Mishra, S.; Kumar, P.; Shukla, Y.; Gupta, K.C. PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma. Int. J. Nanomed. 2015, 10, 6789–6809. [Google Scholar] [CrossRef] [PubMed]
- Guo, L.; Peng, Y.; Li, Y.; Jingping, Y.; Guangmei, Z.; Jie, C.; Jing, W.; Lihua, S. Cell death pathway induced by resveratrol-bovine serum albumin nanoparticles in a human ovarian cell line. Oncol. Lett. 2015, 9, 1359–1363. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Karthikeyan, S.; Hoti, S.L.; Prasad, N.R. Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappa B activation, and induces apoptosis in non-small cell lung cancer cells. Biomed. Pharmacother. 2015, 70, 274–282. [Google Scholar] [CrossRef] [PubMed]
- Kumar, S.; Lather, V.; Pandita, D. A facile green approach to prepare core–shell hybrid PLGA nanoparticles for resveratrol delivery. Int. J. Biol. Macromol. 2016, 84, 380–384. [Google Scholar] [CrossRef] [PubMed]
- Sanna, V.; Siddiqui, I.A.; Sechi, M.; Mukhtar, H. Resveratrol-loaded nanoparticles based on polyepsiloncaprolactone and polyd,l-lacticco-glycolic acid-polyethylene glycol blend for prostate cancer treatment. Mol. Pharm. 2013, 10, 3871–3881. [Google Scholar] [CrossRef] [PubMed]
- Guo, W.; Li, A.; Jia, Z.; Yuan, Y.; Dai, H.; Li, H. Transferrin modified PEG-PLA resveratrol conjugates, in vitro and in vivo studies for glioma. Eur. J. Pharmacol. 2013, 718, 41–47. [Google Scholar] [CrossRef] [PubMed]
- David, K.I.; Jaidev, L.R.; Sethuraman, S.; Krishnan, U.M. Dual drug loaded chitosan nanoparticles–sugar-coated arsenal against pancreatic cancer. Colloids Surf. B Biointerfaces 2015, 135, 689–698. [Google Scholar] [CrossRef] [PubMed]
- Jain, A.K.; Thanki, K.; Jain, S. Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles, implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol. Pharm. 2013, 10, 3459–3474. [Google Scholar] [CrossRef] [PubMed]
- Abbad, S.; Waddad, A.Y.; Lv, H.; Zhou, J. Preparation, in vitro and in vivo evaluation of Polymeric nanoparticles based on hyaluronic acid Polybutyl cyanoacrylate and D-alpha-tocopheryl Polyethylene glycol 1000 succinate for tumor-targeted delivery of Morin hydrate. Int. J. Nanomed. 2015, 10, 305–320. [Google Scholar]
- Sirova, M.; Kabesova, M.; Kovar, L.; Etrych, T.; Strohalm, J.; Ulbrich, K.; Rihova, B. HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death. Curr. Med. Chem. 2013, 20, 4815–4826. [Google Scholar] [CrossRef] [PubMed]
- Sobczak, M.; Debek, C.; Oledzka, E.; Kozłowski, R. Polymeric systems of antimicrobial peptides-strategies and potential applications. Molecules 2013, 18, 14122–14137. [Google Scholar] [CrossRef] [PubMed]
- Spizzirri, U.G.; Cirillo, G.; Picci, N.; Iemma, F. Recent development in the synthesis of eco-friendly polymeric antioxidants. Curr. Org. Chem. 2014, 18, 2912–2927. [Google Scholar] [CrossRef]
- Nyanhongo, G.S.; Nugroho Prasetyo, E.; Herrero Acero, E.; Guebitz, G.M. Engineering strategies for successful development of functional polymers using oxidative enzymes. Chem. Eng. Technol. 2012, 35, 1359–1372. [Google Scholar] [CrossRef]
- Oliver, S.; Vittorio, O.; Cirillo, G.; Boyer, C. Enhancing the therapeutic effects of polyphenols with macromolecules. Polym. Chem. 2016, 7, 1529–1544. [Google Scholar] [CrossRef]
- Li, J.; Wang, Y.; Yang, C.; Wang, P.; Oelschlager, D.K.; Zheng, Y.; Tian, D.A.; Grizzle, W.E.; Buchsbaum, D.J.; Wan, M. Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Mol. Pharmacol. 2009, 76, 81–90. [Google Scholar] [CrossRef] [PubMed]
- Safavy, A.; Raisch, K.P.; Mantena, S.; Sanford, L.L.; Sham, S.W.; Krishna, N.R.; Bonner, J.A. Design and development of water-soluble curcumin conjugates as potential anticancer agents. J. Med. Chem. 2007, 50, 6284–6288. [Google Scholar] [CrossRef] [PubMed]
- Dey, S.; Ambattu, L.A.; Hari, P.R.; Rekha, M.R.; .Sreenivasan, K. Glutathione-bearing fluorescent polymer–curcumin conjugate enables simultaneous drug delivery and label-free cellular imaging. Polym. UK 2015, 75, 25–33. [Google Scholar] [CrossRef]
- Wang, W.; Zhang, L.; Le, Y.; Chen, J.F.; Wang, J.; Yun, J. Synergistic effect of PEGylated resveratrol on delivery of anticancer drugs. Int. J. Pharm. 2016, 498, 134–141. [Google Scholar] [CrossRef] [PubMed]
- Wang, X.; Chen, Y.; Dahmani, F.Z.; Yin, L.; Zhou, J.; Yao, J. Amphiphilic carboxymethyl chitosan–quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Biomaterials 2014, 35, 7654–7665. [Google Scholar] [CrossRef] [PubMed]
- Lv, L.; Guo, Y.; Shen, Y.; Liu, J.; Zhang, W.; Zhou, D.; Guo, S. Intracellularly degradable, self-assembled amphiphilic block copolycurcumin nanoparticles for efficient in vivo cancer chemotherapy. Adv. Heal. Mater. 2015, 4, 1496–1501. [Google Scholar] [CrossRef] [PubMed]
- Shpaisman, N.; Sheihet, L.; Bushman, J.; Winters, J.; Kohn, J. One-step synthesis of biodegradable curcumin-derived hydrogels as potential soft tissue fillers after breast cancer surgery. Biomacromolecules 2012, 13, 2279–2286. [Google Scholar] [CrossRef] [PubMed]
- Su, J.; Chen, F.; Cryns, V.L.; Messersmith, P.B. Catechol polymers for pH-responsive, targeted drug delivery to cancer cells. J. Am. Chem. Soc. 2011, 133, 11850–11853. [Google Scholar] [CrossRef] [PubMed]
- Liang, K.; Ng, S.; Lee, F.; Lim, J.; Chung, J.E.; Lee, S.S.; Kurisawa, M. Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels. Acta Biomater. 2016, 33, 142–152. [Google Scholar] [CrossRef] [PubMed]
- Vittorio, O.; Cirillo, G.; Iemma, F.; Di Turi, G.; Jacchetti, E.; Curcio, M.; Barbuti, S.; Funel, N.; Parisi, O.I.; Puoci, F.; et al. Dextran-catechin conjugate, a potential treatment against the pancreatic ductal adenocarcinoma. Pharm. Res. 2012, 29, 2601–2614. [Google Scholar] [CrossRef] [PubMed]
- Vittorio, O.; Brandl, M.; Cirillo, G.; Kimpton, K.; Hinde, E.; Gaus, K.; Yee, E.; Kumar, N.; Duong, H.; Fleming, C.; et al. Dextran–catechin, an anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth. Oncotarget 2016, 7, 47479–47493. [Google Scholar] [CrossRef] [PubMed]
- Puoci, F.; Morelli, C.; Cirillo, G.; Curcio, M.; Parisi, O.I.; Maris, P.; Sisci, D.; Picci, N. Anticancer activity of a quercetin-based polymer towards HeLa cancer cells. Anticancer Res. 2012, 32, 2843–2847. [Google Scholar] [PubMed]
- Cirillo, G.; Kraemer, K.; Fuessel, S.; Puoci, F.; Curcio, M.; Spizzirri, U.G.; Altimari, I.; Iemma, F. Biological activity of a gallic acid–gelatin conjugate. Biomacromolecules 2010, 11, 3309–3315. [Google Scholar] [CrossRef] [PubMed]
- Bhattacharya, K.; Mukherjee, S.P.; Gallud, A.; Burkert, S.C.; Bistarelli, S.; Bellucci, S.; Bottini, M.; Star, A.; Fadeel, B. Biological interactions of carbon-based nanomaterials, from coronation to degradation. Nanomed. Nanotechnol. Biol. Med. 2016, 12, 333–351. [Google Scholar] [CrossRef] [PubMed]
- Bianco, A.; Kostarelos, K.; Partidos, C.D.; Prato, M. Biomedical applications of functionalized carbon nanotubes. Chem. Commun. 2005, 5, 571–577. [Google Scholar] [CrossRef] [PubMed]
- Feng, L.; Liu, Z. Graphene in biomedicine, opportunities and challenges. Nanomed. Lond. 2011, 6, 317–324. [Google Scholar] [CrossRef] [PubMed]
- Wang, Y.; Li, Z.; Wang, J.; Jinghong, L.; Yuehe, L. Graphene and graphene oxide, biofunctionalization and applications in biotechnology. Trends Biotechnol. 2011, 29, 205–212. [Google Scholar] [CrossRef] [PubMed]
- Peng, C.; Hu, W.; Zhou, Y.; Fan, C.; Huang, Q. Intracellular imaging with a graphene-based fluorescent probe. Small 2010, 6, 1686–1692. [Google Scholar] [CrossRef] [PubMed]
- Makharza, S.; Cirillo, G.; Bachmatiuk, A.; Imad, I.; Nicholas, I.; Barbara, T.; Silke, H.; Mark, H.R. Graphene oxidebased drug delivery vehicles, functionalization, characterization, and cytotoxicity evaluation. J. Nanopart Res. 2013, 15, 2099. [Google Scholar] [CrossRef]
- Lin, Y.; Taylor, S.; Li, H.; Shiral, K.A.F.; Liangwei, Q.; Wei, W.; Lingrong, G.; Bing, Z.; Ya-Ping, S. Advances toward bioapplications of carbon nanotubes. J. Mater. Chem. 2004, 14, 527–541. [Google Scholar] [CrossRef]
- Zhang, Y.; Petibone, D.; Xu, Y.; Mahmood, M.; Karmakar, A.; Casciano, D.; Ali, S.; Biris, A.S. Toxicity and efficacy of carbon nanotubes and graphene, the utility of carbon-based nanoparticles in nanomedicine. Drug Metab. Rev. 2014, 46, 232–246. [Google Scholar] [CrossRef] [PubMed]
- Wang, H.; Wang, J.; Deng, X.; Un, H.; Shi, Z.; Gu, Z.; Liu, Y.; Zhao, Y. Biodistribution of carbon single-wall carbon nanotubes in mice. J. Nanosci. Nanotechnol. 2004, 4, 1019–1024. [Google Scholar] [CrossRef] [PubMed]
- Chaudhuri, P.; Soni, S.; Sengupta, S. Single-walled carbon nanotube-conjugated chemotherapy exhibits increased therapeutic index in melanoma. Nanotechnology 2010, 21, 025102. [Google Scholar] [CrossRef] [PubMed]
- Kiew, S.F.; Kiew, L.V.; Lee, H.B.; Imae, T.; Chung, L.Y. Assessing biocompatibility of graphene oxide-based nanocarriers, a review. J. Control. Release 2016, 226, 217–228. [Google Scholar] [CrossRef] [PubMed]
- Bagri, A.; Mattevi, C.; Acik, M.; Chabal, Y.J.; Chhowalla, M.; Shenoy, V.B. Structural evolution during the reduction of chemically derived graphene oxide. Nat. Chem. 2010, 2, 581–587. [Google Scholar] [CrossRef] [PubMed]
- Ambrosi, A.; Chua, C.K.; Khezri, B.; Sofer, Z.; Webster, R.D.; Pumera, M. Chemically reduced graphene contains inherent metallic impurities present in parent natural and synthetic graphite. Proc. Natl. Acad. Sci. USA 2012, 109, 12899–12904. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Spizzirri, U.G.; Hampel, S.; Cirillo, G.; Maria, V.M.; Orazio, V.; Paolina, C.; Cristina, G.; Manuela, C.; Nevio, P.; Francesca, L. Functional gelatin–carbon nanotubes nanohybrids with enhanced antibacterial activity. Int. J. Polym. Mater. Polym. Biomater. 2015, 64, 439–447. [Google Scholar] [CrossRef]
- Spizzirri, U.G.; Curcio, M.; Cirillo, G.; Spataro, T.; Vittorio, O.; Picci, N.; Hampel, S.; Iemma, F.; Nicoletta, F.P. Recent advances in the synthesis and biomedical applications of nanocomposite hydrogels. Pharmaceutics 2015, 7, 413–437. [Google Scholar] [CrossRef] [PubMed]
- Kim, S.J.; Lee, J.M.; Kumer, R.A.; Park, S.Y.; Kim, S.C.; In, I. Environmentally friendly synthesis of P-doped reduced graphene oxide with high dispersion stability by using red table wine. Chem. Asian J. 2015, 10, 1192–1197. [Google Scholar] [CrossRef] [PubMed]
- Abdolahad, M.; Janmaleki, M.; Mohajerzadeh, S.; Akhavan, O.; Abbasi, S. Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells. Mater. Sci. Eng. C 2013, 33, 1498–1505. [Google Scholar] [CrossRef] [PubMed]
- Gurunathan, S.; Han, J.W.; Kim, E.S.; Park, J.H.; Kim, J.H. Reduction of graphene oxide by resveratrol, a novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule. Int. J. Nanomed. 2015, 10, 2951–2969. [Google Scholar] [CrossRef] [PubMed]
- Cirillo, G.; Hampel, S.; Klingeler, R.; Puoci, F.; Iemma, F.; Curcio, M.; Parisi, O.I.; Spizzirri, U.G.; Picci, N.; Leonhardt, A.; et al. Antioxidant multiwalled carbon nanotubes by free radical grafting of gallic acid, new materials for biomedical applications. J. Pharm. Pharmacol. 2011, 63, 179–188. [Google Scholar] [CrossRef] [PubMed]
- Shao, S.; Li, L.; Yang, G.; Li, J.; Luo, C.; Gong, T.; Zhou, S. Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. Int. J. Pharm. 2011, 421, 310–320. [Google Scholar] [CrossRef] [PubMed]
- Cirillo, G.; Vittorio, O.; Hampel, S.; Spizzirri, U.G.; Picci, N.; Iemma, F. Incorporation of carbon nanotubes into a gelatin-catechin conjugate, innovative approach for the preparation of anticancer materials. Int. J. Pharm. 2013, 446, 176–182. [Google Scholar] [CrossRef] [PubMed]
- Castro Nava, A.; Cojoc, M.; Peitzsch, C.; Cirillo, G.; Kurth, I.; Fuessel, S.; Erdmann, K.; Kunhardt, D.; Vittorio, O.; Hampel, S.; et al. Development of novel radiochemotherapy approaches targeting prostate tumor progenitor cells using nanohybrids. Int. J. Cancer 2016, 137, 2492–2503. [Google Scholar] [CrossRef] [PubMed]
- Cirillo, G.; Vittorio, O.; Hampel, S.; Iemma, F.; Parchi, P.; Cecchini, M.; Puoci, F.; Picci, N. Quercetin nanocomposite as novel anticancer therapeutic, improved efficiency and reduced toxicity. Eur. J. Pharm. Sci. 2013, 49, 359–365. [Google Scholar] [CrossRef] [PubMed]
- Vittorio, O.; Brandl, M.; Cirillo, G.; Umile, G.S.; Nevio, P.; Maria, K.; Francesca, L.; Silke, H. Novel functional cisplatin carrier based on carbon nanotubes-quercetin nanohybrid induces synergistic anticancer activity against neuroblastoma in vitro. RSC Adv. 2014, 4, 31378–31384. [Google Scholar] [CrossRef]
- Riggio, C.; Calatayud, M.P.; Giannaccini, M.; Sanz, B.; Torres, T.E.; Fernández-Pacheco, R.; Ripoli, A.; Ibarra, M.R.; Dente, L.; Cuschieri, A.; et al. The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field. Nanomed. Nanotechnol. Biol. Med. 2014, 10, 1549–1558. [Google Scholar] [CrossRef] [PubMed]
- Ası´n, L.; Goya, G.F.; Tres, A.; Ibarra, M.R. Induced cell toxicity originates dendritic cell death following magnetic hyperthermia treatment. Cell. Death Dis. 2013, 4, e596. [Google Scholar] [CrossRef] [PubMed]
- Manju, S.; Sreenivasan, K. Enhanced drug loading on magnetic nanoparticles by layer-by-layer assembly using drug conjugates, blood compatibility evaluation and targeted drug delivery in cancer cells. Langmuir 2011, 27, 14489–14496. [Google Scholar] [CrossRef] [PubMed]
- Wani, K.D.; Kitture, R.; Ahmed, A.; Choudhari, AS.; Koppikar, SJ.; Kale, SN.; Kaul-Ghanekar, R. Synthesis, characterization and in vitro study of curcumin-functionalized citric acid-capped magnetic CCF nanoparticles as drug delivery agents in cancer. J. Bionanosci. 2011, 5, 59–65. [Google Scholar] [CrossRef]
- Yallapu, M.M.; Ebeling, M.C.; Khan, S.; Sundram, V.; Chauhan, N.; Gupta, B.K.; Puumala, S.E.; Jaggi, M.; Chauhan, S.C. Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. Mol. Cancer Ther. 2013, 12, 1471–1480. [Google Scholar] [CrossRef] [PubMed]
- Vittorio, O.; Voliani, V.; Faraci, P.; Karmakar, B.; Iemma, F.; Hampel, S.; Kavallaris, M.; Cirillo, G. Magnetic catechin-dextran conjugate as targeted therapeutic for pancreatic tumour cells. J. Drug Target 2014, 22, 408–415. [Google Scholar] [CrossRef] [PubMed]
- Xiao, L.; Mertens, M.; Wortmann, L.; Kremer, S.; Valldor, M.; Lammers, T.; Kiessling, F.; Mathur, S. Enhanced in vitro and in vivo cellular imaging with green tea coated water-soluble iron oxide nanocrystals. ACS Appl. Mater. Interfaces 2015, 7, 6530–6540. [Google Scholar] [CrossRef] [PubMed]
- Guo, D.; Wu, C.; Li, J.; Guo, A.; Li, Q.; Jiang, H.; Chen, B.; Wang, X. Synergistic effect of functionalized nickel nanoparticles and quercetin on inhibition of the SMMC-7721 cells proliferation. Nanoscale Res. Lett. 2009, 4, 1395–1402. [Google Scholar] [CrossRef] [PubMed]
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model/In Vivo Model Promisingly Ttreated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Polyvinyl pyrrolidone–PEG | Emulsion evaporation | Plant polyphenols | Glioblastoma DBTRG-05MG | [28] |
2 | Keratin | Solvent evaporation | Curcumin | Cervical cancer HeLa | [29] |
3 | Gelatin | Solvent evaporation | Curcumin | Lung cancer H1299 | [30] |
4 | PEG–Oleic acid | Thin layer evaporation | Curcumin | Brain cancer U87MG | [42] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model/In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Gelatin–Dextran | Self-assembly-Genipin-Crosslinking | Plant polyphenols | Breast cancer MCF-7 | [26] |
2 | Gelatin–Dextran | Self-assembly-Genipin-Crosslinking | Curcumin | Cervical cancer HeLa Healthy mice | [27] |
3 | Casein | Self-assembly | Curcumin | Cervical cancer HeLa | [32] |
4 | Zein–PEG | Self-assembly | Curcumin | Ovarian cancer NCI Healthy mice | [33] |
5 | Chitosan–Stearic acid | Self-assembly | Curcumin | Colon cancer Primary Xenograft mice | [34] |
6 | PEG–Polyanhydride esters | Solvent evaporation | Curcumin | Cervical cancer HeLa | [35] |
7 | PEG–Polylactic acid | Solvent evaporation | Curcumin + Doxorubicin | Breast cancer MCF-7 Xenograft mice | [36] |
8 | PEG–Polycaprolactone | Thin-layer evaporation | Curcumin | Ovarian cancer A2780t | [38] |
9 | PEG–Polycaprolactone | Thin-layer evaporation | Curcumin | Breast cancer MDA-MB-436 | [37] |
10 | PEG–Polycaprolactone | Self-assembly | Curcumin | Breast cancer 4T1–4T1 Xenograft mice | [40] |
11 | PEG–Polycaprolactone | Thin-layer evaporation | Curcumin | Cervical cancer HeLa Xenograft mice | [39] |
12 | PEG–Polycaprolactone | Thin-layer evaporation | Curcumin | Colon HT-29 | [39] |
13 | PEG–Polycaprolactone | Thin-layer evaporation | Curcumin + Doxorubicin | Lung cancer LL/2 Xenograft mice | [41] |
14 | Linoleic acid-PEG-Polycaprolactone | Self-assembly | Curcumin | Cervical cancer HeLa Healthy mice | [43] |
15 | Linoleic acid-PEG-Polycaprolactone | Self-assembly | Curcumin | Lung A549 | [43] |
16 | PEG -Palmitic acid | Self-assembly | Curcumin | Cervical cancer HeLa | [32] |
17 | PEG2000-DSPE | Thin-layer evaporation | Curcumin + Paclitaxel | Ovarian cancer SK-OV-3TR | [45] |
18 | PEG2000-DSPE | Thin-layer evaporation | Curcumin + Paclitaxel | Ovarian cancer NCI SK-OV-3TR Xenograft mice | [46] |
19 | PEG2000-DSPE | Thin-layer evaporation | Curcumin + Doxorubicin | Colon cancer HCT-116 Xenograft mice | [44] |
20 | PEG- Doxorubicin | Self-assembly | Curcumin + Doxorubicin | Cervical cancer HeLa HepG2 Xenograft mice | [47] |
21 | PEG-Doxorubicin | Self-assembly | Curcumin + Doxorubicin | Hepatic HepG2 | [47] |
22 | Poloxamers F127 F68 | Thin-layer evaporation | Curcumin | Cervical cancer HeLa | [48] |
23 | Poloxamers-PEG-Succinate | Solvent evaporation | Curcumin | Ovarian cancer NCI | [49] |
24 | Poloxamers F127 | Thin-layer evaporation | Resveratrol, Curcumin + Doxorubicin | Ovarian cancer SKOV-3 Healthy mice | [50] |
25 | Poloxamers F127 | Thin-layer evaporation | Resveratrol, Quercetin + Doxorubicin | Ovarian cancer SKOV-3 Healthy mice | [31] |
26 | Apolipoprotein-E3 | recombinant DNA | Resveratrol | Glioblastoma A-172 | [51] |
27 | Polycaprolactone-PEG-Succinate | Thin-layer evaporation | Resveratrol | Breast cancer MCF-7 | [52] |
28 | Casein | Self-assembly | Epigallocatechin gallate | Colon cancer HT-29 | [53] |
29 | Polylactic acid-PEG | Thin-layer evaporation | Epigallocatechin gallate | Pancreatic cancer MiaPaca-2 | [54] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Polylactic-co-glycolic acid PLGA–PEG | Emulsion solvent evaporation | Pomgranade polyphenols | Breast cancer MCF-7, Hs578T | [61] |
2 | Chitosan | Ionic gelation | Tea polyphenols | Hepatic cancer Hep G2 | [62] |
3 | Polycaprolactone | EXP | Plant polyphenols | Gastric cancer MNK28 | [63] |
4 | Alginate–Chitosan–Poloxamers F127 | Ionic gelation | Curcumin | Cervical cancer HeLa | [64] |
5 | Fibrinogen | CaCl2 Crosslinking | Curcumin | Prostate cancer PC3 | [65] |
6 | PLGA | Emulsion solvent evaporation | Curcumin | Breast cancer MCF-7 | [65] |
7 | PLGA | Emulsion solvent evaporation | Curcumin | Osteosarcoma U2OS | [66] |
8 | Chitin | Emulsion solvent evaporation | Curcumin | Melanoma A375 | [67] |
9 | Peptide | Ionic gelation | Curcumin | Medulloblastoma DAOY | [68] |
10 | N-Isopropylacrylamide-N-vinyl-2-pyrrolidone-Polyethylene glycol acrylate | Self-assembly | Curcumin | Pancreatic cancer Capan-1, MiaPaCa2, PL-5, PL-8, Su86.86, BxPC-3, PANC-1, E3LZ10.7 Healthy mice | [69] |
11 | PLGA–PEG | Nanoprecipitation | Curcumin | Colon cancer HT-29 Healthy mice | [70] |
12 | PLGA | Nanoprecipitation | Curcumin | Ovarian cancer A2780, A2780CP | [71] |
13 | Cellulose | Nanoprecipitation | Curcumin | Prostate cancer C4-2, PC-3, LNCaP, DU-145 | [72] |
14 | PLGA | Nanoprecipitation | Curcumin | Prostate cancer DU-145, PC-3 Xenograft mice | [73] |
15 | Human serum albumin | Emulsion solvent evaporation | Curcumin | Colon cancer HCT116 HCT116 Xenograft mice | [74] |
16 | Human serum albumin | Emulsion solvent evaporation | Curcumin | Pancreatic cancer MiaPaCa2 | [74] |
17 | Gelatin–Polyacryl-amidoglycolic acid | Emulsion polymerization | Curcumin | Colon cancer HCT-116 | [75] |
18 | Silk fibroin | Physical adsorption and coprecipitation | Curcumin | Human hepatocellular carcinoma Hep3B, human neuroblastoma Kelly cells, Human bone marrow-derived mesenchymal stem cells hBMSCs | [76] |
19 | Chitosan–Polybutyl cyanoacrylate | Emulsion polymerization | Curcumin + Doxorubicin | Breast cancer MCF-7 | [77] |
20 | PLGA | Emulsion solvent evaporation | Curcumin + 5-fluorouracil | Breast cancer MCF-7 | [78] |
21 | PLGA | Nanoprecipitation | Curcumin + Cisplatin | Ovarian cancer A2780CP | [79] |
22 | PLGA | Nanoprecipitation | Curcumin + Cisplatin | Breast cancer MDA-MB-231 | [79] |
23 | N-Isopropylacryl-amide-N-vinyl-2-pyrrolidone–Acrylic acid | Radical polymerization | Curcumin + Gemcitabine | Pancreatic cancer Pa03C Xenograft mice | [80] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Gelatin–Polyelectrolyte | Layer-by-layer | Epigallocatechin gallate | Breast cancer MBA-MD-231 | [81] |
2 | PLGA–PEG | Nanoprecipitation | Epigallocatechin gallate | Prostate cancer LNCaP | [82] |
3 | Casein-phospho-peptide–Chitosan | Genipin-Crosslinking | Epigallocatechin gallate | Hepatic cancer HepG2 | [83] |
4 | Casein-phospho-peptide–Chitosan | Genipin-Crosslinking | Epigallocatechin gallate | Gastric cancer BGC823 | [83] |
5 | Casein-phospho-peptide–Chitosan | Genipin-Crosslinking | Epigallocatechin gallate | Colon cancer Caco-2 | [84] |
6 | Hyaluronic acid | Self-assembly | Epigallocatechin gallate + Doxorubicin | Cancer of the external auditory canal | [85] |
8 | Chitosan | Ionic gelation | Epigallocatechin gallate | Prostate cancer 22R_1 Xenograft mice | [87] |
7 | Chitosan | Ionic gelation | Epigallocatechin gallate | Melanoma Mel928 Mel928 Xenograft mice | [88] |
9 | Chitosan–Gelatin–PEG | Ionic gelation | Epigallocatechin gallate | Gastric cancer Luc MKN45 Xenograft mice | [88] |
10 | PLGA | Nanoprecipitation | Epigallocatechin gallate + Cisplatin | Lung cancer A549 | [89] |
11 | PLGA | Nanoprecipitation | Epigallocatechin gallate + Cisplatin | Cervical cancer HeLA | [89] |
12 | PLGA | Nanoprecipitation | Theaflavin | Leukemia THP-1 | [89] |
13 | PLGA | Solvent evaporation | Epigallocatechin gallate + Cisplatin | Lung cancer A549 Ehrlich ascites carcinoma Xenograft mice | [90] |
14 | PLGA | Solvent evaporation | Epigallocatechin gallate | Cervical cancer HeLA | [90] |
15 | PLGA | Solvent evaporation | Theaflavin | Leukemia THP-1 | [90] |
16 | PLGA | Solvent evaporation | Theaflavin | Cancer of the external auditory canal | [90] |
17 | PLGA–PEG | Nanoprecipitation | Resveratrol | Prostate cancer DU-145, LNCaP | [91] |
18 | Bovine serum albumin | Nanoprecipitation | Resveratrol | Lung cancer NCI-H460 | [92] |
19 | Bovine serum albumin | Nanoprecipitation | Resveratrol | Ovarian cancer SKOV3 | [93] |
20 | PLGA | Emulsion method | Resveratrol | Breast cancer MCF-7 | [94] |
21 | Maleimide–PEG–Polylactic acid | Self-assembly | Resveratrol | Glioblastoma CT26, U87 CT26 Xenograft mice | [95] |
22 | Chitosan | Ionic gelation | Quercetin + 5-fluorouracil | Pancreas cancer MiaPaCa2 | [96] |
23 | PLGA | Emulsion solvent evaporation | Quercetin + Tamoxifen | Breast cancer MCF-7 Xenograft mice | [97] |
24 | PLGA | Emulsion solvent evaporation | Quercetin + Tamoxifen | Colon cancer Caco2 | [97] |
25 | Hyaluronic acid–Polybutyl cyanoacrylate–a-Tocopheryl–PEG–Succinate | Radical polymerization | Morin hydrate | Lung cancer A549 S180 Xenograft mice | [98] |
26 | Hyaluronic acid–Polybutyl cyanoacrylate –Tocopheryl–PEG–Succinate | Radical polymerization | Morin hydrate | Hepatic cancer L02 | [98] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | PEG | Condensation method | Curcumin | Glioma C6 | [106] |
2 | PEG | Condensation method | Curcumin | Prostate cancer PC-3 | [105] |
3 | PEG | Condensation method | Curcumin + Gemcitabine | Pancreatic cancer MiaPaCa2, PANC-1, BxPC-3, AsPC-1 | [104] |
4 | PEG | Condensation method | Resveratrol + Bicalutamide | Cervical cancer HeLa | [107] |
5 | PEG | Condensation method | Resveratrol + Bicalutamide | Breast cancer MCF-7 | [107] |
6 | Carboxymethyl chitosan | Condensation method | Quercetin + Paclitaxel | Hepatic cancer HepG2 HepG2 Xenograft mice | [108] |
7 | PEG | Condensation method | Curcumin | Cervical cancer HeLa, Breast cancer EMT6 EMT6 Xenograft mice | [109] |
8 | PEG–Desaminotyrosyl-tyrosine ethyl ester | Condensation method | Curcumin | Breast cancer MDA-MB-231 | [110] |
9 | PEG | Condensation method | Catechin + Bortezomib | Breast cancer MDA-MB-231 | [111] |
10 | Hyaluronic acid–Polyethyleneimine | Condensation method | Epigallocatechin gallate + Granzyme B | Colon cancer HCT-116 | [112] |
11 | Dextran | Free radical grafting | Catechin | Pancreatic cancer MiaPaca-2, PL45 | [113] |
12 | Dextran | Free radical grafting | Catechin | Neuroblastoma IMR-32, IMR-32-CisRes, BE2-C Xenograft mice | [114] |
13 | Dextran | Enzyme laccase catalysis | Catechin | Neuroblastoma IMR-32 | [114] |
14 | Polymethacrylic acid | Free radical grafting | Quercetin | Cervical cancer HeLa | [115] |
15 | Gelatin | Free radical grafting | Gallic acid | Prostate cancer DU-145, PC-3 | [116] |
16 | Gelatin | Free radical grafting | Gallic acid | Renal cancer A498 | [116] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model/In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Graphene oxide | Reduction method | Tea polyphenols | Colon cancer HT29, SW48 | [133] |
2 | Graphene oxide | Reduction method | Resveratrol | Ovarian cancer A2780 | [134] |
3 | Polycapro-lactone–MWNT | Electrospinning | Tea polyphenols | Lung cancer A549 | [136] |
4 | Polycapro-lactone–MWNT | Electrospinning | Tea polyphenols | Hepatic HepG2 | [136] |
5 | Gelatin–MWNT | Coating | Catechin + Radiotherapy | Prostate cancer DY-145, PC-3, LNCap | [138] |
6 | Gelatin–MWNT | Coating | Catechin | Cervical cancer HeLa | [139] |
7 | Polymeth-acrylic acid–MWNT | Radical coupling | Quercetin | Cervical cancer HeLa | [137] |
8 | Polymeth-acrylic acid–MWNT | Radical coupling | Quercetin + Cisplatin | Neuroblastoma IMR-32 | [140] |
No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model/In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
---|---|---|---|---|---|
1 | Hyaluronic acid–Iron | Layer-by-layer | Curcumin | Colon cancer Caco-2 | [143] |
2 | Polyvinyl pyrrolidone–Iron | Layer-by-layer | Curcumin | Glioma C6 | [143] |
3 | Iron–Poloxamers F127 | Nanopre-cipitation | Curcumin | Pancreatic cancer HPAF-II, Panc-1/Xenograft mice | [145] |
Iron–Dextran | Solvation method | Catechin | Pancreatic cancer MIA Paca2 | [146] | |
4 | Iron | Reduction process | Epigallocatechin gallate | Colon cancer CT-26/Xenograft mice | [147] |
5 | Nickel | Electro-chemical deposition | Quercetin | Hepatic cancer SMMC-7721 | [148] |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Ernest, U.; Chen, H.-Y.; Xu, M.-J.; Taghipour, Y.D.; Asad, M.H.H.B.; Rahimi, R.; Murtaza, G. Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics. Molecules 2018, 23, 2787. https://doi.org/10.3390/molecules23112787
Ernest U, Chen H-Y, Xu M-J, Taghipour YD, Asad MHHB, Rahimi R, Murtaza G. Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics. Molecules. 2018; 23(11):2787. https://doi.org/10.3390/molecules23112787
Chicago/Turabian StyleErnest, Umeorah, Hai-Yan Chen, Ming-Jun Xu, Yasamin Davatgaran Taghipour, Muhammad Hassham Hassan Bin Asad, Roja Rahimi, and Ghulam Murtaza. 2018. "Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics" Molecules 23, no. 11: 2787. https://doi.org/10.3390/molecules23112787