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Molecules 2018, 23(10), 2611; https://doi.org/10.3390/molecules23102611

SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice

1
Department of Histology & Embryology and Medical Genetics, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, China
2
Department of Anatomy, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, China
*
Authors to whom correspondence should be addressed.
Received: 2 September 2018 / Revised: 29 September 2018 / Accepted: 9 October 2018 / Published: 11 October 2018
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Abstract

Skin wound healing is a complex and dynamic process that involves angiogenesis and growth factor secretion. Newly formed vessels can provide nutrition and oxygen for skin wound healing. Growth factors in skin wounds are important for keratinocytes and fibroblasts proliferation, epithelialization, extracellular matrix remodeling, and angiogenesis, which accelerate skin wound healing. Therefore, treatment strategies that enhance angiogenesis and growth factors secretion in skin wounds can accelerate skin wound healing. This study investigated the effects of a SIKVAV (Ser-Ile-Lys-Val-Ala-Val) peptide-modified chitosan hydrogel on skin wound healing. Hematoxylin and eosin (H&E) staining demonstrated that the SIKVAV-modified chitosan hydrogel accelerated the re-epithelialization of wounds compared with that seen in the negative and positive controls. Masson’s trichrome staining showed that more collagen fibers were deposited in the skin wounds treated with the SIKVAV-modified chitosan hydrogel than in the negative and positive controls. Immunohistochemistry assays demonstrated that more myofibroblasts were deposited and more angiogenesis occurred in skin wounds treated with the SIKVAV-modified chitosan hydrogel than in the negative and positive controls. In addition, ELISA assays showed that the SIKVAV-modified chitosan hydrogels promoted the secretion of growth factors in skin wounds. Taken together, these results suggest that the SIKVAV-modified chitosan hydrogel has the potential to be developed as synthesized biomaterials for the treatment of skin wounds. View Full-Text
Keywords: SIKVAV; chitosan hydrogel; skin wound healing; angiogenesis; growth factor SIKVAV; chitosan hydrogel; skin wound healing; angiogenesis; growth factor
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Chen, X.; Cao, X.; Jiang, H.; Che, X.; Xu, X.; Ma, B.; Zhang, J.; Huang, T. SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice. Molecules 2018, 23, 2611.

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