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Open AccessArticle

Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

by Yalin Hu 2,†, Li Heng 1,†, Rong Xu 1, Junhe Li 2, Shanshan Wei 2, Deran Xu 2, Jun Luo 2 and Yi Li 1,*
1
Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, China
2
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Molecules 2018, 23(10), 2590; https://doi.org/10.3390/molecules23102590
Received: 3 September 2018 / Revised: 29 September 2018 / Accepted: 1 October 2018 / Published: 10 October 2018
(This article belongs to the Section Natural Products Chemistry)
Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages. View Full-Text
Keywords: Melia toosendan; limonoids; modified Mosher’s method; ECD exciton chirality; anti-inflammatory Melia toosendan; limonoids; modified Mosher’s method; ECD exciton chirality; anti-inflammatory
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MDPI and ACS Style

Hu, Y.; Heng, L.; Xu, R.; Li, J.; Wei, S.; Xu, D.; Luo, J.; Li, Y. Meliacarpinin-Type Limonoids from the Bark of Melia toosendan. Molecules 2018, 23, 2590.

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