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Molecules 2018, 23(1), 79; https://doi.org/10.3390/molecules23010079

Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review

1
Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, IMSS, Mexico City 06720, Mexico
2
Health Department, Universidad Iberoamericana, Mexico City 01219, Mexico
3
Instituto Nacional de Pediatría, Mexico City 04530, Mexico
*
Author to whom correspondence should be addressed.
Received: 15 September 2017 / Revised: 3 October 2017 / Accepted: 11 October 2017 / Published: 29 December 2017
(This article belongs to the Special Issue 25th Anniversary of the Amyloid Hypothesis and Alzheimer Disease)
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Abstract

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones. View Full-Text
Keywords: biomarker; conformational diseases; Alzheimer’s disease; diabetes mellitus; amyloid oligomers; cytotoxic oligomers biomarker; conformational diseases; Alzheimer’s disease; diabetes mellitus; amyloid oligomers; cytotoxic oligomers
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Avila-Vazquez, M.F.; Altamirano-Bustamante, N.F.; Altamirano-Bustamante, M.M. Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review. Molecules 2018, 23, 79.

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