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Molecules 2018, 23(1), 27; https://doi.org/10.3390/molecules23010027

Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

1
Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
2
Faculty of Pharmacy, National Yang-Ming University, Taipei 11221, Taiwan
3
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
4
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 10617, Taiwan
5
Department of Chemistry, Chung-Yuan Christian University, Chungli 32023, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 20 November 2017 / Revised: 14 December 2017 / Accepted: 20 December 2017 / Published: 22 December 2017
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created. View Full-Text
Keywords: malonamide; Staphylococcus aureus; antibiotics malonamide; Staphylococcus aureus; antibiotics
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Su, J.-C.; Huang, Y.-T.; Chen, C.-S.; Chiu, H.-C.; Shiau, C.-W. Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus. Molecules 2018, 23, 27.

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