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Molecules 2017, 22(9), 1487;

Silver Oxide Coatings with High Silver-Ion Elution Rates and Characterization of Bactericidal Activity

Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028, USA
Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA
Department of Electrical and Computer Engineering, Rowan University, Glassboro, NJ 08028, USA
Department of Molecular Biology, Rowan University, Stratford, NJ 08084, USA
Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028, USA
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 7 August 2017 / Revised: 29 August 2017 / Accepted: 30 August 2017 / Published: 7 September 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
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This paper reports the synthesis and characterization of silver oxide films for use as bactericidal coatings. Synthesis parameters, dissolution/elution rate, and bactericidal efficacy are reported. Synthesis conditions were developed to create AgO, Ag2O, or mixtures of AgO and Ag2O on surfaces by reactive magnetron sputtering. The coatings demonstrate strong adhesion to many substrate materials and impede the growth of all bacterial strains tested. The coatings are effective in killing Escherichia coli and Staphylococcus aureus, demonstrating a clear zone-of-inhibition against bacteria growing on solid media and the ability to rapidly inhibit bacterial growth in planktonic culture. Additionally, the coatings exhibit very high elution of silver ions under conditions that mimic dynamic fluid flow ranging between 0.003 and 0.07 ppm/min depending on the media conditions. The elution of silver ions from the AgO/Ag2O surfaces was directly impacted by the complexity of the elution media, with a reduction in elution rate when examined in complex cell culture media. Both E. coli and S. aureus were shown to bind ~1 ppm Ag+/mL culture. The elution of Ag+ resulted in no increases in mammalian cell apoptosis after 24 h exposure compared to control, but apoptotic cells increased to ~35% by 48 and 72 h of exposure. Taken together, the AgO/Ag2O coatings described are effective in eliciting antibacterial activity and have potential for application on a wide variety of surfaces and devices. View Full-Text
Keywords: bactericidal coatings; antibacterial; silver oxide; reactive sputtering; thin film coatings bactericidal coatings; antibacterial; silver oxide; reactive sputtering; thin film coatings

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Goderecci, S.S.; Kaiser, E.; Yanakas, M.; Norris, Z.; Scaturro, J.; Oszust, R.; Medina, C.D.; Waechter, F.; Heon, M.; Krchnavek, R.R.; Yu, L.; Lofland, S.E.; Demarest, R.M.; Caputo, G.A.; Hettinger, J.D. Silver Oxide Coatings with High Silver-Ion Elution Rates and Characterization of Bactericidal Activity. Molecules 2017, 22, 1487.

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