Next Article in Journal
Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine
Previous Article in Journal
Interaction of Flavonoids from Woodwardia unigemmata with Bovine Serum Albumin (BSA): Application of Spectroscopic Techniques and Molecular Modeling Methods
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(8), 1319;

Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
College of Chemistry and Chemical Engineering, Ocean University of China, Songling Road 238, Qingdao 266100, China
Cancer Research institute, Binzhou Medical University Hospital, Yellow river second Road 661, Binzhou 256603, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 18 July 2017 / Revised: 2 August 2017 / Accepted: 7 August 2017 / Published: 9 August 2017
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [839 KB, uploaded 10 August 2017]   |  


A chemical investigation was conducted on the aerial parts of the mangrove plant Sonneratia paracaseolaris, yielding five new triterpenoid paracaseolins A–E (14, and 11) together with twelve known analogues (510, 1217). Their structures were established by extensive spectroscopic methods and comparisons their spectroscopic data with those of the known related compounds. The cytotoxicities against P388, HeLa, A549, and K562 tumor cell lines and anti-H1N1 (Influenza A virus) activities for the isolates were evaluated. Compound 4 showed potent cytotoxicity against the A549 cell line with an IC50 value of 1.89 µM, and compound 1 exhibited significant anti-H1N1 virus activity with an IC50 value of 28.4 µg/mL. A preliminary structure activity relationship was discussed. View Full-Text
Keywords: mangrove plant; Sonneratia paracaseolaris; triterpenoids; cytotoxicities; anti-H1N1 activities mangrove plant; Sonneratia paracaseolaris; triterpenoids; cytotoxicities; anti-H1N1 activities

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Gong, K.-K.; Li, P.-L.; Qiao, D.; Zhang, X.-W.; Chu, M.-J.; Qin, G.-F.; Tang, X.-L.; Li, G.-Q. Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris. Molecules 2017, 22, 1319.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top