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Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Hong Kong Baptist University Shenzhen Research Institute and Continuing Education, 518057 Shenzhen, China
Preparatory Office of Shenzhen-Melbourne Institute of Life Sciences and Bioengineering, Guangzhou University of Chinese Medicine, 510006 Guangzhou, China
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, 650500 Kunming, China
Authors to whom correspondence should be addressed.
Molecules 2017, 22(7), 1218;
Received: 30 June 2017 / Revised: 18 July 2017 / Accepted: 18 July 2017 / Published: 20 July 2017
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation. View Full-Text
Keywords: magnolol; inflammation; ulcerative colitis; tryptophan metabolites magnolol; inflammation; ulcerative colitis; tryptophan metabolites
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MDPI and ACS Style

Zhao, L.; Xiao, H.-t.; Mu, H.-x.; Huang, T.; Lin, Z.-s.; Zhong, L.L.D.; Zeng, G.-z.; Fan, B.-m.; Lin, C.-y.; Bian, Z.-x. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules 2017, 22, 1218.

AMA Style

Zhao L, Xiao H-t, Mu H-x, Huang T, Lin Z-s, Zhong LLD, Zeng G-z, Fan B-m, Lin C-y, Bian Z-x. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017; 22(7):1218.

Chicago/Turabian Style

Zhao, Ling; Xiao, Hai-tao; Mu, Huai-xue; Huang, Tao; Lin, Ze-si; Zhong, Linda L.D.; Zeng, Guang-zhi; Fan, Bao-min; Lin, Cheng-yuan; Bian, Zhao-xiang. 2017. "Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice" Molecules 22, no. 7: 1218.

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