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Co-Transcriptional Folding and Regulation Mechanisms of Riboswitches

Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University, Huanggang 438000, Hubei, China
Department of Physics, Wuhan University, Wuhan 430072, Hubei, China
Author to whom correspondence should be addressed.
Molecules 2017, 22(7), 1169;
Received: 18 June 2017 / Revised: 7 July 2017 / Accepted: 9 July 2017 / Published: 13 July 2017
(This article belongs to the Section Bioorganic Chemistry)
Riboswitches are genetic control elements within non-coding regions of mRNA. These self-regulatory elements have been found to sense a range of small metabolites, ions, and other physical signals to exert regulatory control of transcription, translation, and splicing. To date, more than a dozen riboswitch classes have been characterized that vary widely in size and secondary structure. Extensive experiments and theoretical studies have made great strides in understanding the general structures, genetic mechanisms, and regulatory activities of individual riboswitches. As the ligand-dependent co-transcriptional folding and unfolding dynamics of riboswitches are the key determinant of gene expression, it is important to investigate the thermodynamics and kinetics of riboswitches both in the presence and absence of metabolites under the transcription. This review will provide a brief summary of the studies about the regulation mechanisms of the pbuE, SMK, yitJ, and metF riboswitches based on the ligand-dependent co-transcriptional folding of the riboswitches. View Full-Text
Keywords: riboswitch; gene regulation; co-transcriptional folding riboswitch; gene regulation; co-transcriptional folding
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Gong, S.; Wang, Y.; Wang, Z.; Zhang, W. Co-Transcriptional Folding and Regulation Mechanisms of Riboswitches. Molecules 2017, 22, 1169.

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