Next Article in Journal
Effect of UV-C Radiation, Ultra-Sonication Electromagnetic Field and Microwaves on Changes in Polyphenolic Compounds in Chokeberry (Aronia melanocarpa)
Previous Article in Journal
Comparative Transcriptome Analysis Reveals Adaptive Evolution of Notopterygium incisum and Notopterygium franchetii, Two High-Alpine Herbal Species Endemic to China
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(7), 1159;

Characterization and Biological Evaluation of Propolis from Poland

Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Clinical Oncology Laboratory, University Hospital of Patras, Patras Medical School, 26504 Rio, Greece
Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 20093 Lublin, Poland
Division of Pharmacognosy and Chemistry of Natural Products, Departments of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
Pharmacokinetics Laboratory, Department of Pharmacy, University of Patras, 26504 Rio, Greece
Department of Cosmetology, University of Information Technology and Management in Rzeszow, 35225 Rzeszów, Poland
Authors to whom correspondence should be addressed.
Received: 17 May 2017 / Revised: 6 July 2017 / Accepted: 7 July 2017 / Published: 11 July 2017
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1139 KB, uploaded 13 July 2017]   |  


In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC–MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populus nigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populus tremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95–1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25–1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health. View Full-Text
Keywords: GC–MS; cytotoxic activity; Polish propolis; Populus nigra; Populus tremula GC–MS; cytotoxic activity; Polish propolis; Populus nigra; Populus tremula

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Popova, M.; Giannopoulou, E.; Skalicka-Woźniak, K.; Graikou, K.; Widelski, J.; Bankova, V.; Kalofonos, H.; Sivolapenko, G.; Gaweł-Bęben, K.; Antosiewicz, B.; Chinou, I. Characterization and Biological Evaluation of Propolis from Poland. Molecules 2017, 22, 1159.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top