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Cytotoxic Compounds from Aloe megalacantha

Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Department of Chemistry, College of Natural Sciences, Jimma University, P.O. Box 378, 251 Jimma, Ethiopia
Authors to whom correspondence should be addressed.
Molecules 2017, 22(7), 1136;
Received: 31 May 2017 / Revised: 27 June 2017 / Accepted: 3 July 2017 / Published: 7 July 2017
(This article belongs to the Collection Bioactive Compounds)
PDF [750 KB, uploaded 7 July 2017]


Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound. View Full-Text
Keywords: Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity

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Abdissa, N.; Gohlke, S.; Frese, M.; Sewald, N. Cytotoxic Compounds from Aloe megalacantha. Molecules 2017, 22, 1136.

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