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Molecules 2017, 22(4), 637;

Discovery of an Octahedral Silicon Complex as a Potent Antifungal Agent

College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 February 2017 / Revised: 5 April 2017 / Accepted: 12 April 2017 / Published: 15 April 2017
(This article belongs to the Special Issue Advances in Silicon Chemistry)
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Octahedral transition metal complexes have been shown to have tremendous applications in chemical biology and medicinal chemistry. Meanwhile, structural transition metals can be replaced by inert octahedral silicon in a proof-of-principle study. We here introduce the first example of octahedral silicon complexes, which can very well serve as an efficient antimicrobial agent. The typical silicon arenediolate complex 1 {[(phen)2Si(OO)](PF6)2, with phen = 1,10-phenanthroline, OO = 9,10-phenanthrenediolate} exhibited significant inhibition towards the growth of Cryptococcus neoformans with MIC and MFC values of 4.5 and 11.3 μM, respectively. Moreover, it was fungicidal against both proliferative and quiescent Cryptococcus cells. This work may set the stage for the development of novel antifungal drugs based upon hexacoodinate silicon scaffolds. View Full-Text
Keywords: silicon; octahedral complex; antimicrobial activity; antifungal agent silicon; octahedral complex; antimicrobial activity; antifungal agent

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fu, C.; Fu, B.; Peng, X.; Liao, G. Discovery of an Octahedral Silicon Complex as a Potent Antifungal Agent. Molecules 2017, 22, 637.

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