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Na+i,K+i-Dependent and -Independent Signaling Triggered by Cardiotonic Steroids: Facts and Artifacts
Review

Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

1
Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro RJ CEP 21040-900, Brazil
2
Laboratorio de Imunofarmacologia, Departamento de Bioquímica, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro RJ CEP 20211-010, Brazil
3
Laboratório de Enzimologia e Sinalização Celular, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói RJ CEP 24020-141, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Diego Muñoz-Torrero
Molecules 2017, 22(4), 578; https://doi.org/10.3390/molecules22040578
Received: 21 February 2017 / Revised: 29 March 2017 / Accepted: 29 March 2017 / Published: 21 April 2017
(This article belongs to the Special Issue Cardiotonic Steroids)
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy. View Full-Text
Keywords: Na/K-ATPase; non-small cell lung cancer; cardiotonic steroids; apoptosis; autophagy Na/K-ATPase; non-small cell lung cancer; cardiotonic steroids; apoptosis; autophagy
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MDPI and ACS Style

Felippe Gonçalves-de-Albuquerque, C.; Ribeiro Silva, A.; Ignácio da Silva, C.; Caire Castro-Faria-Neto, H.; Burth, P. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Molecules 2017, 22, 578. https://doi.org/10.3390/molecules22040578

AMA Style

Felippe Gonçalves-de-Albuquerque C, Ribeiro Silva A, Ignácio da Silva C, Caire Castro-Faria-Neto H, Burth P. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Molecules. 2017; 22(4):578. https://doi.org/10.3390/molecules22040578

Chicago/Turabian Style

Felippe Gonçalves-de-Albuquerque, Cassiano, Adriana Ribeiro Silva, Camila Ignácio da Silva, Hugo Caire Castro-Faria-Neto, and Patrícia Burth. 2017. "Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy" Molecules 22, no. 4: 578. https://doi.org/10.3390/molecules22040578

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