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Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro RJ CEP 21040-900, Brazil
Laboratorio de Imunofarmacologia, Departamento de Bioquímica, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro RJ CEP 20211-010, Brazil
Laboratório de Enzimologia e Sinalização Celular, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói RJ CEP 24020-141, Brazil
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Diego Muñoz-Torrero
Molecules 2017, 22(4), 578;
Received: 21 February 2017 / Revised: 29 March 2017 / Accepted: 29 March 2017 / Published: 21 April 2017
(This article belongs to the Special Issue Cardiotonic Steroids)
PDF [1267 KB, uploaded 21 April 2017]


Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy. View Full-Text
Keywords: Na/K-ATPase; non-small cell lung cancer; cardiotonic steroids; apoptosis; autophagy Na/K-ATPase; non-small cell lung cancer; cardiotonic steroids; apoptosis; autophagy

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Felippe Gonçalves-de-Albuquerque, C.; Ribeiro Silva, A.; Ignácio da Silva, C.; Caire Castro-Faria-Neto, H.; Burth, P. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Molecules 2017, 22, 578.

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