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Molecules 2017, 22(3), 483;

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), CNRS UMR 8231, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75231 Paris CEDEX 05, France
Author to whom correspondence should be addressed.
Academic Editors: Margaret A. Brimble CNZM, FRSNZ
Received: 2 March 2017 / Revised: 9 March 2017 / Accepted: 14 March 2017 / Published: 19 March 2017
(This article belongs to the Special Issue Women in Organic Chemistry)


A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition. View Full-Text
Keywords: nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rioton, S.; Pardo, D.G.; Cossy, J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules 2017, 22, 483.

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