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Open AccessFeature PaperReview

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), CNRS UMR 8231, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75231 Paris CEDEX 05, France
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Academic Editors: Margaret A. Brimble CNZM, FRSNZ
Molecules 2017, 22(3), 483; https://doi.org/10.3390/molecules22030483
Received: 2 March 2017 / Revised: 9 March 2017 / Accepted: 14 March 2017 / Published: 19 March 2017
(This article belongs to the Special Issue Women in Organic Chemistry)
A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition. View Full-Text
Keywords: nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition
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MDPI and ACS Style

Rioton, S.; Pardo, D.G.; Cossy, J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules 2017, 22, 483.

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