Next Article in Journal
In Vitro Activities of LCB 01-0648, a Novel Oxazolidinone, against Gram-Positive Bacteria
Next Article in Special Issue
Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin
Previous Article in Journal
Glycerol as Precursor of Organoselanyl and Organotellanyl Alkynes
Previous Article in Special Issue
Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Molecules 2017, 22(3), 395;

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
Department of Molecular Biology and Biochemistry, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
Author to whom correspondence should be addressed.
Academic Editor: Santosh K. Katiyar
Received: 24 January 2017 / Revised: 27 February 2017 / Accepted: 28 February 2017 / Published: 3 March 2017
(This article belongs to the Special Issue Cancer Chemoprevention)
Full-Text   |   PDF [1005 KB, uploaded 3 March 2017]   |  


Phytochemicals are an important part of traditional medicine and have been investigated in detail for possible inclusion in modern medicine as well. These compounds often serve as the backbone for the synthesis of novel therapeutic agents. For many years, phytochemicals have demonstrated encouraging activity against various human cancer models in pre-clinical assays. Here, we discuss select phytochemicals—curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, plumbagin and honokiol—in the context of their reported effects on the processes of inflammation and oxidative stress, which play a key role in tumorigenesis. We also discuss the emerging evidence on modulation of tumor microenvironment by these phytochemicals which can possibly define their cancer-specific action. Finally, we provide recent updates on how low bioavailability, a major concern with phytochemicals, is being circumvented and the general efficacy being improved, by synthesis of novel chemical analogs and nanoformulations. View Full-Text
Keywords: phytochemicals; cancer chemoprevention; tumor microenvironment; inflammation; pro-oxidant; nanotechnology phytochemicals; cancer chemoprevention; tumor microenvironment; inflammation; pro-oxidant; nanotechnology

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zubair, H.; Azim, S.; Ahmad, A.; Khan, M.A.; Patel, G.K.; Singh, S.; Singh, A.P. Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch. Molecules 2017, 22, 395.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top