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Molecules 2017, 22(12), 2077;

An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways

Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, China
Department of Chemical Engineering, Xinjiang Institutes of Engineering, Urumqi 830091, Xinjiang, China
University of the Chinese Academy of Sciences, Beijing 100039, China
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 22 November 2017 / Accepted: 24 November 2017 / Published: 28 November 2017
(This article belongs to the Section Chemical Biology)
Full-Text   |   PDF [5555 KB, uploaded 28 November 2017]   |  


Plants or plant-derived products have been routinely used in several traditional medicine systems for vitiligo treatment. It is well-known that melanogenesis can be promoted by certain flavonoid compounds isolated from the traditional Uyghur medicinal plant, Kaliziri. Therefore, Chalcones, one class of flavonoid compounds, has become an interesting target for the development of anti-vitiligo agents. A series of novel isoxazole chalcone derivatives have been designed, synthesized, and evaluated for biological activities by our group. Among them, derivative 1-(4-((3-phenylisoxazol-5-yl)methoxy)phenyl)-3-phenylprop-2-en-1-one (PMPP) was identified as a potent tyrosinase activator with better activity and lower toxicity than the positive control 8-methoxypsoralen (8-MOP) in this study. Further investigations revealed that Akt and GSK3β were the signaling pathways involved in the hyperpigmentation of PMPP. Overall, these studies may provide a convenient and novel approach for the further development of anti-vitiligo agents. View Full-Text
Keywords: chalcone derivative; PI3K/Akt; Wnt/β-catenin; melanogenesis; B16 melanoma chalcone derivative; PI3K/Akt; Wnt/β-catenin; melanogenesis; B16 melanoma

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Yin, L.; Niu, C.; Liao, L.-X.; Dou, J.; Habasi, M.; Aisa, H.A. An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways. Molecules 2017, 22, 2077.

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