Next Article in Journal
Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H1 Receptor Antagonist
Next Article in Special Issue
Two-Ply Composite Membranes with Separation Layers from Chitosan and Sulfoethylcellulose on a Microporous Support Based on Poly(diphenylsulfone-N-phenylphthalimide)
Previous Article in Journal
Capillary Electrophoresis Hyphenated with Mass Spectrometry for Determination of Inflammatory Bowel Disease Drugs in Clinical Urine Samples
Previous Article in Special Issue
Chitosan/Cyclodextrin/TPP Nanoparticles Loaded with Quercetin as Novel Bacterial Quorum Sensing Inhibitors
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(11), 1980;

Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride

Department of Physical Chemistry II. Pharmacy Faculty, Biofuncional Studies Institute, Complutense University, Paseo Juan XXIII, 1, 28040 Madrid, Spain
Center of Biomaterials, University of Havana Ave. Universidad s/n entre G y Ronda, Vedado, 10400 La Habana, Cuba
Author to whom correspondence should be addressed.
Received: 8 October 2017 / Revised: 7 November 2017 / Accepted: 9 November 2017 / Published: 15 November 2017
Full-Text   |   PDF [2977 KB, uploaded 16 November 2017]   |  


Venlafaxine controlled drug delivery systems using different matrixes have been tested to reduce undesirable side effects in the treatment of depression. The legal status of chitosan (Cs) in Pharmacy has dramatically improved after its acceptance as excipient in several Pharmacopeias and, therefore, there is great interest in pharmaceutical formulations based on this polymer. In this paper, chitosan microcapsules cross-linked with sodium tripolyphosphate (TPP) for oral delivery of venlafaxine were formulated using the spray drying technique. The effect of chitosan physico-chemical properties, TPP concentration and TPP/Cs ratio on drug release was evaluated. The microcapsules were characterized in terms of size, zeta potential and morphology. The physical state of the drug was determined by X-ray diffraction (XRD) and the drug release from the microcapsules was studied in simulated gastric and intestinal fluids. The release pattern fitted well to the Peppas-Koersmeyer model with n exponents indicating anomalous transport. View Full-Text
Keywords: microcapsules; modelling; functional characterization; venlafaxine; drug release microcapsules; modelling; functional characterization; venlafaxine; drug release

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Aranaz, I.; Paños, I.; Peniche, C.; Heras, Á.; Acosta, N. Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride. Molecules 2017, 22, 1980.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top