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Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy

Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
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Molecules 2017, 22(10), 1761; https://doi.org/10.3390/molecules22101761
Received: 31 August 2017 / Revised: 14 October 2017 / Accepted: 17 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Bioactive Compounds for Metabolic Syndrome and Type 2 Diabetes)
Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight. These results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes. View Full-Text
Keywords: hops; xanthohumol; iso-α-acids; matured hop bitter acids; metabolic syndrome; obesity; diabetes; cholesterol hops; xanthohumol; iso-α-acids; matured hop bitter acids; metabolic syndrome; obesity; diabetes; cholesterol
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Dostálek, P.; Karabín, M.; Jelínek, L. Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy. Molecules 2017, 22, 1761.

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