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Open AccessArticle

Heat Shock Protein-Inducing Property of Diarylheptanoid Containing Chalcone Moiety from Alpinia katsumadai

by Joo-Won Nam 1,* and Yun-Sil Lee 2
1
College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbukdo 38541, Korea
2
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
*
Author to whom correspondence should be addressed.
Molecules 2017, 22(10), 1750; https://doi.org/10.3390/molecules22101750
Received: 26 September 2017 / Revised: 14 October 2017 / Accepted: 16 October 2017 / Published: 17 October 2017
(This article belongs to the Section Natural Products Chemistry)
A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity. View Full-Text
Keywords: Alpinia katsumadai; diarylheptanoid; chalcone; heat shock protein (HSP); heat shock factor (HSF) Alpinia katsumadai; diarylheptanoid; chalcone; heat shock protein (HSP); heat shock factor (HSF)
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MDPI and ACS Style

Nam, J.-W.; Lee, Y.-S. Heat Shock Protein-Inducing Property of Diarylheptanoid Containing Chalcone Moiety from Alpinia katsumadai. Molecules 2017, 22, 1750.

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