Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone
Abstract
:1. Introduction
2. Results and Discussion
2.1. Thermal Analysis
2.2. X-ray Fluorescence
2.3. X-ray Diffraction
2.4. Fourier Transform Infrared (FT-IR)
2.5. Scanning Electron Microscopy (SEM)
2.6. Hygroscopicity
2.7. Partition Coefficient/Lipophilicity
2.8. Solubility
3. Trypanocidal Activity
4. Materials and Methods
4.1. Material
4.2. Differential Scanning Calorimetry (DSC)
4.3. Termogravimetry & Differential Thermal Analysis (TG and DTA)
4.4. X-ray Fluorescence
4.5. X-ray Diffraction
4.6. Fourrier Transform Infrared (FT-IR)
4.7. Scanning Electron Microscopy (SEM)
4.8. Hygroscopicity
4.9. Partition Coefficient/Lipophilicity
4.10. Solubility Studies
4.11. Parasites
4.12. Anti-Parasitic Activity
4.13. Inverse Virtual Screening
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample Availability: Samples of the compound IVS320 are available from the authors. |
Chemical Element | Concentration ‰ (w/w) |
---|---|
Na | 22.13 |
Mg | 0.579 |
Al | 0.615 |
S | 0.03 |
Cu | 0.01 |
Classification | Criteria |
---|---|
Non-hygroscopic | No moisture increase at humidity levels below 90%. Less than 20% (w/w) increase in moisture content at humidity levels above 90% after 1 week of storage. |
Slightly hygroscopic | No moisture increase at humidity levels below 80%. Less than 40% (w/w) increase in moisture content at humidity levels above 80% after 1 week of storage. |
Moderately hygroscopic | Moisture content does not increase >5% (w/w) at humidity levels below 60%. Less than 50% (w/w) increase in moisture content at humidity levels above 80% after 1 week of storage. |
Very hygroscopic | Moisture content increases at humidity levels as low as 40–50%. Greater than 20% (w/w) increase in moisture content at humidity levels above 90% after week of storage. |
Data | LogP * |
---|---|
1 | 2.04 |
2 | 2.13 |
3 | 2.07 |
Data | Solubility (μg/mL) * |
---|---|
1 | 0.0108 |
2 | 0.0134 |
3 | 0.0122 |
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Share and Cite
Dantas, E.D.; De Souza, F.J.J.; Nogueira, W.N.L.; Silva, C.C.; De Azevedo, P.H.A.; Soares Aragão, C.F.; Almeida, P.D.O.d.; Cardoso, M.F.d.C.; Da Silva, F.D.C.; De Azevedo, E.P.; et al. Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone. Molecules 2017, 22, 1631. https://doi.org/10.3390/molecules22101631
Dantas ED, De Souza FJJ, Nogueira WNL, Silva CC, De Azevedo PHA, Soares Aragão CF, Almeida PDOd, Cardoso MFdC, Da Silva FDC, De Azevedo EP, et al. Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone. Molecules. 2017; 22(10):1631. https://doi.org/10.3390/molecules22101631
Chicago/Turabian StyleDantas, Elen Diana, Fabia Julliana Jorge De Souza, William Nascimento Litaiff Nogueira, Cláudia Cândida Silva, Pedro Henrique Antunes De Azevedo, Cícero Flávio Soares Aragão, Patricia Danielle Oliveira de Almeida, Mariana Filomena do Carmo Cardoso, Fernando De Carvalho Da Silva, Eduardo Pereira De Azevedo, and et al. 2017. "Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone" Molecules 22, no. 10: 1631. https://doi.org/10.3390/molecules22101631