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Open AccessArticle

Melandrii Herba Extract Attenuates H2O2-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells and Scopolamine-Induced Memory Impairment in Mice

Korea Food Research Institute, Seongnam-si, Gyeonggi-do 13539, Korea
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Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Molecules 2017, 22(10), 1646; https://doi.org/10.3390/molecules22101646
Received: 29 August 2017 / Revised: 20 September 2017 / Accepted: 26 September 2017 / Published: 30 September 2017
(This article belongs to the Section Natural Products Chemistry)
Oxidative stress plays a significant role in the etiology of a variety of neurodegenerative diseases. In this study, we found that Melandrii Herba extract (ME) attenuated oxidative-induced damage in cells. Mechanistically, ME exhibited protection from H2O2-induced neurotoxicity via caspase-3 inactivation, Bcl-2 downregulation, Bax upregulation, and MAPK activation (ERK 1/2, JNK 1/2, and p38 MAPK) in vitro. Moreover, our in vivo data showed that ME was able to attenuate scopolamine-induced cognitive impairment. These results provide in vitro and in vivo evidence that ME exhibits neuroprotective properties against oxidative stress, which suggests that ME is worthy of further investigation as a complementary, or even as an alternative, product for preventing and treating neurodegenerative disorders. View Full-Text
Keywords: Melandrii Herba extract; neurotoxicity; oxidative stress; scopolamine; cell survival Melandrii Herba extract; neurotoxicity; oxidative stress; scopolamine; cell survival
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Lee, K.M.; Lee, A.S.; Choi, I. Melandrii Herba Extract Attenuates H2O2-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells and Scopolamine-Induced Memory Impairment in Mice. Molecules 2017, 22, 1646.

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