Next Article in Journal
Role of Electron-Driven Proton-Transfer Processes in the Ultrafast Deactivation of Photoexcited Anionic 8-oxoGuanine-Adenine and 8-oxoGuanine-Cytosine Base Pairs
Next Article in Special Issue
Regulation of T Cell Activation and Differentiation by Extracellular Vesicles and Their Pathogenic Role in Systemic Lupus Erythematosus and Multiple Sclerosis
Previous Article in Journal
Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology
Previous Article in Special Issue
Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview

Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders

Department of Rheumatology and Immunology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Author to whom correspondence should be addressed.
Academic Editor: Chun Kwok Wong
Molecules 2017, 22(1), 134;
Received: 12 December 2016 / Revised: 5 January 2017 / Accepted: 10 January 2017 / Published: 14 January 2017
PDF [768 KB, uploaded 14 January 2017]


A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases. View Full-Text
Keywords: Th17-cells; regulatory T-cells; autoimmunity; RORγt; Foxp3 Th17-cells; regulatory T-cells; autoimmunity; RORγt; Foxp3

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Fasching, P.; Stradner, M.; Graninger, W.; Dejaco, C.; Fessler, J. Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders. Molecules 2017, 22, 134.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top