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Open AccessCommunication

Atom-Economic Synthesis of 4-Pyrones from Diynones and Water

1
College of Pharmacy, Guilin Medical University, Guilin 541004, China
2
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Georgiy B. Shul’pin
Molecules 2017, 22(1), 109; https://doi.org/10.3390/molecules22010109
Received: 21 December 2016 / Revised: 5 January 2017 / Accepted: 5 January 2017 / Published: 10 January 2017
(This article belongs to the Special Issue Reactions of Hydrocarbons and other C‒H Compounds)
Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones. View Full-Text
Keywords: 4-pyrones; diynones; water; transition-metal-free 4-pyrones; diynones; water; transition-metal-free
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MDPI and ACS Style

Xu, Y.-L.; Teng, Q.-H.; Tong, W.; Wang, H.-S.; Pan, Y.-M.; Ma, X.-L. Atom-Economic Synthesis of 4-Pyrones from Diynones and Water. Molecules 2017, 22, 109.

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