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Molecules 2017, 22(1), 109;

Atom-Economic Synthesis of 4-Pyrones from Diynones and Water

College of Pharmacy, Guilin Medical University, Guilin 541004, China
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Georgiy B. Shul’pin
Received: 21 December 2016 / Revised: 5 January 2017 / Accepted: 5 January 2017 / Published: 10 January 2017
(This article belongs to the Special Issue Reactions of Hydrocarbons and other C‒H Compounds)
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Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones. View Full-Text
Keywords: 4-pyrones; diynones; water; transition-metal-free 4-pyrones; diynones; water; transition-metal-free

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xu, Y.-L.; Teng, Q.-H.; Tong, W.; Wang, H.-S.; Pan, Y.-M.; Ma, X.-L. Atom-Economic Synthesis of 4-Pyrones from Diynones and Water. Molecules 2017, 22, 109.

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