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Molecules 2016, 21(9), 1112;

Three New Isoprenylated Flavonoids from the Root Bark of Morus alba

Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea
Natural Medicine Research Center, KRIBB, Chengju 28116, Korea
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Korea
Division of Metabolism and Functionality Research, Korea Food Research Institute, Sungnam 463-746, Korea
Author to whom correspondence should be addressed.
Academic Editors: Arturo San Feliciano and Celestino Santos-Buelga
Received: 12 July 2016 / Revised: 16 August 2016 / Accepted: 19 August 2016 / Published: 24 August 2016
(This article belongs to the Special Issue Flavonoids: From Structure to Health Issues)
Full-Text   |   PDF [797 KB, uploaded 24 August 2016]   |  


Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a7 (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO2), octadecyl SiO2 (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 14 were isolated for the first time from the root bark of M. alba in this study. View Full-Text
Keywords: isoprenylated flavonoids; Morus alba; root bark; sanggenon U; sanggenon V; sanggenon W isoprenylated flavonoids; Morus alba; root bark; sanggenon U; sanggenon V; sanggenon W

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    Description: 1H-NMR, 13C-NMR, HMBC, and MS spectra are available as supporting data. Supplementary materials can be accessed at:

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Jung, J.-W.; Park, J.-H.; Lee, Y.-G.; Seo, K.-H.; Oh, E.-J.; Lee, D.-Y.; Lim, D.-W.; Han, D.; Baek, N.-I. Three New Isoprenylated Flavonoids from the Root Bark of Morus alba. Molecules 2016, 21, 1112.

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