Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. Test Compounds
3.2. Disc Diffusion Bioassay
3.3. Dose–Response Bioassay
3.4. Competitive Antagonism Bioassay
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
QS | Quorum sensing |
AHL | N-acylated homoserine lactone |
HSL | Homoserine lactone |
MIC | Minimum inhibitory concentration |
GFP | green fluorescent protein |
OHHL | 3-oxo-hexanoyl-HSL |
YP | yeast peptone media |
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- Sample Availability: Samples of the compounds 8–26 are available from the authors
Compound | IC50 (µM) | MIC (µM) | Compound | IC50 (µM) | MIC (µM) |
---|---|---|---|---|---|
8 | inactive | >1000 | 18 | 23 | >1000 |
9 | 76 | >1000 | 19 | 53 | 1000 |
10 | inactive | >1000 | 20 | 81 | 500 |
11 | 87 | >1000 | 21 | 39 | 500 |
12 | inactive | >1000 | 22 | 36 | >1000 |
13 | inactive | >1000 | 23 | 41 | >1000 |
14 | 96 | >1000 | 24 | 53 | >1000 |
15 | 56 | >1000 | 25 | 71 | >1000 |
16 | inactive | 1000 | 26 | inactive | >1000 |
17 | 92 | 1000 |
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Forschner-Dancause, S.; Poulin, E.; Meschwitz, S. Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters. Molecules 2016, 21, 971. https://doi.org/10.3390/molecules21080971
Forschner-Dancause S, Poulin E, Meschwitz S. Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters. Molecules. 2016; 21(8):971. https://doi.org/10.3390/molecules21080971
Chicago/Turabian StyleForschner-Dancause, Stephanie, Emily Poulin, and Susan Meschwitz. 2016. "Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters" Molecules 21, no. 8: 971. https://doi.org/10.3390/molecules21080971