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Molecules 2016, 21(8), 1050;

Achillea schurii Flowers: Chemical, Antioxidant, and Antimicrobial Investigations

Department of Pharmacognosy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 I. Creangă Street, Cluj-Napoca 400010, Romania
Department of Bromatology, Hygiene, Nutrition, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, Cluj-Napoca 400349, Romania
Department of Chemistry and Chemical Engineering, “Babeş-Bolyai” University, 11 A. Janos Street, Cluj-Napoca 400028, Romania
Department of Pharmaceutical Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 V. Babeş Street, Cluj-Napoca 400012, Romania
Department of Pharmaceutical Technology and Biopharmaceutics, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 I. Creanga Street, Cluj-Napoca 400010, Romania
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 28 June 2016 / Revised: 3 August 2016 / Accepted: 9 August 2016 / Published: 12 August 2016
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1001 KB, uploaded 12 August 2016]   |  


This study aims to evaluate the phenolic profile, and antioxidant and antimicrobial activity of Achillea schurii Sch.-Bip., an endemic species from Romania that has not been investigated yet. The chromatographic profile of the phenolic components was obtained using the HPLC-MS method, while the total polyphenol, flavonoid, caffeic acid derivative contents were quantified using spectrophotometric methods. The antioxidant activity was evaluated using different methods: DPPH radical scavenging, hemoglobin ascorbate peroxidase activity inhibition (HAPX), inhibition of lipid peroxidation catalyzed by cytochrome c, and direct detection of plant-derived free radicals using electron paramagnetic resonance (EPR). The antimicrobial test was performed using the disk diffusion assay. The phenolic profile has revealed high amounts of isoquercitrin, rutin, luteolin, and apigenin. The A. schurii extract exhibited a good antioxidant capacity, and high phenolic contents (76.93 mg/g polyphenols, 18.61 mg/g flavonoids and 41.48 mg/g caffeic acid derivatives, respectively). The antimicrobial tests reveal a remarkable inhibitory activity against Listeria monocytogenes, Staphylococcus aureus, and Salmonella typhimurium. Considering the above, A. schurii may be deemed to offer good perspectives for pharmaceutical and industrial applications. View Full-Text
Keywords: polyphenols; Achillea schurii; antioxidant; antimicrobial; hemoglobin; cytochrome c polyphenols; Achillea schurii; antioxidant; antimicrobial; hemoglobin; cytochrome c

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Benedec, D.; Hanganu, D.; Oniga, I.; Filip, L.; Bischin, C.; Silaghi-Dumitrescu, R.; Tiperciuc, B.; Vlase, L. Achillea schurii Flowers: Chemical, Antioxidant, and Antimicrobial Investigations. Molecules 2016, 21, 1050.

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